2-氯-4-甲基-3-硝基吡啶合成路线 （共 31 条）
反应条件
1: 75 percent / H2 / 5percent Rh/C / ethanol / 3 h / 2585.7 Torr 2: 65.5 percent / pyridine / cyclohexane; dioxane / 48 h / Ambient temperature 3: xylene / Heating 4: NaH / various solvent(s) / Heating 5: 1.) NaH / 1.) DMSO, 2.) DMSO View Scheme
参考文献
Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241
反应条件
1: 75 percent / H2 / 5percent Rh/C / ethanol / 3 h / 2585.7 Torr 2: 65.5 percent / pyridine / cyclohexane; dioxane / 48 h / Ambient temperature 3: xylene / Heating 4: NaH / various solvent(s) / Heating View Scheme
参考文献
Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241
反应条件
hydrogenchloride; tin(ll) chloride in diethyl ether 0.333333 h; Ambient temperature;
参考文献
Norman; Minick; Martin
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 3 p. 771 - 779
反应条件
sodium hydroxide; acetic acid in hydrogenchloride; water
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US5366972 A1, 1994 ;
反应条件
1: 98 percent / SnCl2 * 2 H2O, conc. HCl / diethyl ether / 0.33 h / Ambient temperature 2: 87 percent / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) RT, 23 h View Scheme
参考文献
Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241
反应条件
1: acetic acid; sodium acetate; palladium/charcoal / Hydrogenation 2: ethyl nitrite; petroleum ether / Diazotization 3: KMnO4; H2O 4: SOCl2 / Erwaermen des Reaktionsgemisches mit Aethanol View Scheme
参考文献
Roe; Seligman
Journal of Organic Chemistry, 1955 , vol. 20, p. 1729,1731
反应条件
potassium dichromate; sulfuric acid T=60°C; 8 h;
参考文献
Beijing Yiling Bioengineering Co., Ltd.
Patent: EP2366691 A1, 2011 ;
Location in patent: Page/Page column 7-8 ;
反应条件
1: 98 percent / SnCl2 * 2 H2O, conc. HCl / diethyl ether / 0.33 h / Ambient temperature 2: 87 percent / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) RT, 23 h 3: 94 percent / 4 h / 140 °C 4: 67 percent / 80percent NaH / bis-(2-methoxy-ethyl) ether / 1.5 h / 185 °C View Scheme
参考文献
Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241
反应条件
in methanol 2 h; Heating;
参考文献
Evans; Furneaux; Hutchison; Kezar; Morris, Jr.; Schramm; Tyler
Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5723 - 5730
反应条件
1: 98 percent / methanol / 2 h / Heating 2: 99 percent / dimethylformamide / 18 h / 130 °C 3: 89 percent / H2 / Pd/C / ethanol / 0.25 h / 775.74 Torr View Scheme
参考文献
Evans; Furneaux; Hutchison; Kezar; Morris, Jr.; Schramm; Tyler
Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5723 - 5730
