2-氯-5-甲基-3-硝基吡啶合成路线 （共 19 条）
反应条件
N-benzyl-N,N,N-trimethyl-ammonium chloride; trichlorophosphate in acetonitrile 6 h; Heating;
参考文献
Ahn, Sung Oh; Park, Chan Hee; Im, Jun Hwan; Lee, Soon Ok; Lee, Kyoung June; Cho, Seong Wook; Ko, Kwang Seok; Han, Sun Young; Lee, Won Il
Patent: US2011/28467 A1, 2011 ;
Location in patent: Page/Page column 51 ;
US 20110028467 A1
反应条件
1: sulfuric acid; nitric acid / water / 18 h / 60 °C 2: thionyl chloride / N,N-dimethyl-formamide / 3 h / 110 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 13 p. 3983 - 3987
反应条件
1.1: nitric acid; sulfuric acid / 2 h / 0 - 5 °C 1.2: 4 h / Cooling with ice 2.1: trichlorophosphate / 5 h / Reflux View Scheme
反应条件
in ethanol 1 h; Heating;
参考文献
Journal of Molecular Structure, , vol. 748, # 1-3 p. 91 - 100
反应条件
sodium methylate 6 h; Heating;
参考文献
Godard; Rocca; Pomel; Thomas-Dit-Dumont; Rovera; Thaburet; Marsais; Queguiner
Journal of Organometallic Chemistry, 1996 , vol. 517, # 1-2 p. 25 - 36
反应条件
1: 98 percent / sodium methoxide / 6 h / Heating 2: 90 percent / H2 / 10percent Pd/C / ethanol View Scheme
参考文献
Godard; Rocca; Pomel; Thomas-Dit-Dumont; Rovera; Thaburet; Marsais; Queguiner
Journal of Organometallic Chemistry, 1996 , vol. 517, # 1-2 p. 25 - 36
反应条件
1: With ethanol; tin(ll) chloride T=50 - 55°C; 2 h; 2: With sodium hydroxide in dichloromethane; water
参考文献
NEUROGEN CORPORATION
Patent: WO2006/42102 A2, 2006 ;
Location in patent: Page/Page column 49-50 ;
WO 2006/042102 A2
反应条件
1: aq.-ethanolic HCl; NaN3 2: 155 °C View Scheme
参考文献
Boyer; Schoen
Journal of the American Chemical Society, 1956 , vol. 78, p. 423
反应条件
ethanol; hydrazine hydrate
参考文献
Chun, Kwangwoo; Park, Ji-Seon; Lee, Han-Chang; Kim, Young-Ha; Ye, In-Hea; Kim, Kang-Jeon; Ku, Il-Whea; Noh, Min-Young; Cho, Goang-Won; Kim, Heejaung; Kim, Seung Hyun; Kim, Jeongmin
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3983 - 3987
反应条件
1: ethanol; N2H4+H2O 2: aqueous acetic acid; aqueous copper (II)-sulfate solution View Scheme
参考文献
Brown
Journal of the American Chemical Society, 1954 , vol. 76, p. 3167
