2-氯-5-甲基-3-硝基吡啶合成路线 （共 19 条）
反应条件
copper in N,N-dimethyl-formamide T=100 - 105°C; 4 h;
参考文献
Journal of Molecular Structure, , vol. 248, # 1.2 p. 189 - 200
反应条件
sodium dichromate; sulfuric acid T=25°C; 12 h; Cooling with ice;
参考文献
Beijing Yiling Bioengineering Co., Ltd.
Patent: EP2366691 A1, 2011 ;
Location in patent: Page/Page column 9 ;
反应条件
1: powdered copper / dimethylformamide / 4 h / 100 - 105 °C 2: 1) SnCl2, HCl / 1) heating, 30 min, 2) benzene, reflux, 1h 3: 85 percent / 10percent HCl / Heating 4: 1) nitrosylsulfuric acid, 80percent formic acid, 2) water / 1) 0-5 deg C, 30 min, 2) a) 50-60 deg C, b) 90-95 deg C, 10 min View Scheme
参考文献
Kaczmarek, L.; Nowak, B.; Zukowski, J.; Borowicz, P.; Sepiol, J.; Grabowska, A.
Journal of Molecular Structure, 1991 , vol. 248, # 1.2 p. 189 - 200
反应条件
1: ethanol; N2H4+H2O 2: aqueous acetic acid; aqueous copper (II)-sulfate solution 3: KMnO4; H2O View Scheme
参考文献
Brown
Journal of the American Chemical Society, 1954 , vol. 76, p. 3167
反应条件
1: powdered copper / dimethylformamide / 4 h / 100 - 105 °C
2: 1) SnCl2, HCl / 1) heating, 30 min, 2) benzene, reflux, 1h
3: 79 percent / 10percent HCl / Heating
4: 1) nitrosylsulfuric acid, 80percent formic acid, 2) water / 1) 0-5 deg C, 30 min, 2) a) 50-60 deg C, b) 90-95 deg C, 10 min
View Scheme
参考文献
Kaczmarek, L.; Nowak, B.; Zukowski, J.; Borowicz, P.; Sepiol, J.; Grabowska, A.
Journal of Molecular Structure, 1991 , vol. 248, # 1.2 p. 189 - 200
反应条件
1: methanol; potassium hydrogensulfide
2: ethanol; aqueous NaOH-solution; iodine
View Scheme
参考文献
Childress; McKee
Journal of the American Chemical Society, 1951 , vol. 73, p. 3504
参考文献
Childress; McKee
Journal of the American Chemical Society, 1951 , vol. 73, p. 3504
反应条件
1: aq.-ethanolic HCl; NaN3
2: 155 °C
3: ethanol; water; hydroxylamine hydrochloride
View Scheme
参考文献
Boyer; Schoen
Journal of the American Chemical Society, 1956 , vol. 78, p. 423
反应条件
hydrogenchloride; sodium azide
参考文献
Boyer; Schoen
Journal of the American Chemical Society, 1956 , vol. 78, p. 423
