6-(吡咯烷-1-基)吡啶-2-甲醛合成路线 （共 3 条）
反应条件
1: 93 percent / 0.17 h / Heating 2: 1.) t-BuLi / 1.) THF, pentane, -78 deg C, 1 h, 2.) THF, pentane, -78 deg C to rt, rt, overnight View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 13 p. 4652 - 4664
反应条件
tert.-butyl lithium 1.) THF, pentane, -78 deg C, 1 h, 2.) THF, pentane, -78 deg C to rt, rt, overnight; Yield givenMultistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 64, # 13 p. 4652 - 4664
反应条件
1: hydroxylamine hydrochloride; pyridine / ethanol / 1 h / 20 °C / |Inert atmosphere 2: zinc; acetic acid / 3 h / 20 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; KOERNER, Matthias; LERNER, Christian
Patent: WO2013/178569 A1, 2013 ;
