4-羟基双环[2.2.2]辛烷-1-羧酸甲酯合成路线 （共 18 条）
反应条件
1: Py / Heating
2: 165 °C / 760000 Torr
3: H2 / Pd-C
4: aq. KOH
5: (i) AgNO3, aq. NaOH, (ii) Br2
6: NaOH
View Scheme
参考文献
Chapman,N.B. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 917 - 923
反应条件
1: KOH / aq. ethanol / Heating
View Scheme
参考文献
Grob,C.A.; Rich,R.
Helvetica Chimica Acta, 1979 , vol. 62, p. 2802 - 2816
反应条件
1: aq. KOH
2: (i) AgNO3, aq. NaOH, (ii) Br2
3: NaOH
View Scheme
参考文献
Chapman,N.B. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 917 - 923
反应条件
1: (i) AgNO3, aq. NaOH, (ii) Br2
2: NaOH
View Scheme
参考文献
Chapman,N.B. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 917 - 923
参考文献
Chapman,N.B. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 917 - 923
参考文献
Grob,C.A.; Rich,R.
Helvetica Chimica Acta, 1979 , vol. 62, p. 2802 - 2816
Full Text Show Details
Chapman,N.B. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 917 - 923
反应条件
1: 92 percent / SF4 / 24 h / Ambient temperature
2: 96 percent / H2O/KOH / ethanol / 16 h / Ambient temperature
3: 90 percent / diethyl ether; hexane / 2 h / Heating
4: 77 percent / m-chloroperbenzoic acid / CH2Cl2 / 72 h / Ambient temperature
5: 93 percent / NaOMe / methanol / 2 h / Heating
6: 81 percent / SF4 / 24 h / Ambient temperature
View Scheme
参考文献
Adcock, William; Abeywickrema, Anil N.
Journal of Organic Chemistry, 1982 , vol. 47, # 15 p. 2951 - 2957
反应条件
1: 92 percent / SF4 / 24 h / Ambient temperature
2: 96 percent / H2O/KOH / ethanol / 16 h / Ambient temperature
3: thionyl chloride
View Scheme
参考文献
Adcock, William; Abeywickrema, Anil N.
Journal of Organic Chemistry, 1982 , vol. 47, # 15 p. 2951 - 2957
