1.1: [1,3-bis(diphenylphosphino) propane] dichloronickel(II) / diethyl ether / 0 - 25 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / -78 - 0 °C 2.2: 0.5 h / -78 °C 3.1: hydroxylamine hydrochloride; triethylamine / methanol; dichloromethane / 2 h / 25 °C 4.1: dicyclohexyl-carbodiimide / toluene / 15 h / 90 °C 5.1: hydroxylamine / ethanol; water / 1 h / 60 °C 6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; acetonitrile / 0.5 h / 50 °C 7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 50 °C 8.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 °C 8.2: 0 - 25 °C 9.1: sodium hydroxide / 1,4-dioxane; water / 2 h / 25 °C View Scheme

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C 1.2: 97 percent / tetrahydrofuran; hexane / 1 h / -78 °C 2.1: acetic acid; tetrabutylammonium fluoride / tetrahydrofuran / 12 h 3.1: 4 percent / CBr4; triphenylphosphine / tetrahydrofuran / 1 h 4.1: sodium azide / dimethylformamide / 0.5 h / 50 °C 5.1: H2 / 10 percent Pd/C / ethanol / 2 h / 1551.44 Torr View Scheme