8-叔丁基苯并二氢吡喃-4-酮合成路线 （共 5 条）
反应条件
in ethylene glycol 4 h; Reflux;
参考文献
PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas
Patent: WO2012/139775 A1, 2012 ;
Location in patent: Page/Page column 37 ;
WO 2012/139775 A1
反应条件
1: N-chloro-succinimide; silver(I) acetate / acetone / 4 h / Reflux 2: ethylene glycol / 4 h / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 5 p. 1338 - 1341
反应条件
1: potassium carbonate / acetonitrile / 96 h / 20 °C 2: N-chloro-succinimide; silver(I) acetate / acetone / 4 h / Reflux 3: ethylene glycol / 4 h / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 5 p. 1338 - 1341
反应条件
1: pyridine / 24 h / 20 °C 2: palladium 10 on activated carbon; ammonia; hydrogen / methanol / 1 h / 20 °C / 3102.97 Torr View Scheme
参考文献
Schmidt, Robert G.; Bayburt, Erol K.; Latshaw, Steven P.; Koenig, John R.; Daanen, Jerome F.; McDonald, Heath A.; Bianchi, Bruce R.; Zhong, Chengmin; Joshi, Shailen; Honore, Prisca; Marsh, Kennan C.; Lee, Chih-Hung; Faltynek, Connie R.; Gomtsyan, Arthur
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1338 - 1341
反应条件
1: pyridine / 24 h / 20 °C 2: palladium 10 on activated carbon; ammonia; hydrogen / methanol / 1 h / 20 °C / 3102.97 Torr View Scheme
参考文献
Schmidt, Robert G.; Bayburt, Erol K.; Latshaw, Steven P.; Koenig, John R.; Daanen, Jerome F.; McDonald, Heath A.; Bianchi, Bruce R.; Zhong, Chengmin; Joshi, Shailen; Honore, Prisca; Marsh, Kennan C.; Lee, Chih-Hung; Faltynek, Connie R.; Gomtsyan, Arthur
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1338 - 1341
