N-(2-苯基乙基)-甲酰胺合成路线 （共 50 条）
反应条件
triethylamine; trichlorophosphate in dichloromethane T=-10°C; Inert atmosphere;
参考文献
Grolla, Ambra A.; Podesta, Valeria; Chini, Maria Giovanna; Di Micco, Simone; Vallario, Antonella; Genazzani, Armando A.; Canonico, Pier Luigi; Bifulco, Giuseppe; Tron, Gian Cesare; Sorba, Giovanni; Pirali, Tracey
Journal of Medicinal Chemistry, 2009 , vol. 52, # 9 p. 2776 - 2785
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Reflux;
参考文献
BIOENERGENIX; MCCALL, John, M.; MCKEARN, John; ROMERO, Donnal, L.; CLAIR, Michael
Patent: WO2011/28947 A2, 2011 ;
Location in patent: Page/Page column 133-134 ;
WO 2011/028947 A1
反应条件
1: 99 percent / polyphosphoric acid / 1 h / 200 - 220 °C 2: 89 percent / sodium borohydride / ethanol / 1 h / 90 °C 3: 88 percent / pyridine / 3 h / 0 °C 4: 69 percent / tetramethylethylenediamine; t-butyllithium / tetrahydrofuran / 2 h / -78 °C 5: 36 percent / hydrochloric acid / H2O / 24 h / Heating View Scheme
参考文献
Al-Hiari, Yusuf M.; Bennett, Stephen J.; Cox, Brian; Davies, Robert J.; Khalaf, Abedawn I.; Waigh, Roger D.; Worsley, Alan J.
Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 4 p. 647 - 659
反应条件
acetic acid; trifluoroacetic acid
5 h; Heating;
参考文献
Lukanov, Ludmil K.; Venkov, Athanas P.; Mollov, Nikola M.
Synthesis, 1987 , # 11 p. 1031 - 1032
反应条件
trifluoroacetic acid
Pictet-Spengler Cyclisation; 4.5 h; Neat (no solvent)Heating / reflux; Product distribution / selectivity;
参考文献
BASF AKTIENGESELLSCHAFT
Patent: WO2006/134143 A1, 2006 ;
Location in patent: Page/Page column 29 ;
反应条件
trifluoroacetic acid
Pictet-Spengler Cyclisation; 4.5 h; Neat (no solvent)Heating / reflux; Product distribution / selectivity;
参考文献
BASF AKTIENGESELLSCHAFT
Patent: WO2006/134143 A1, 2006 ;
Location in patent: Page/Page column 29 ;
反应条件
1: 99 percent / polyphosphoric acid / 1 h / 200 - 220 °C
2: 89 percent / sodium borohydride / ethanol / 1 h / 90 °C
3: 54 percent / pyridine / 4 h / 0 °C
View Scheme
参考文献
Al-Hiari, Yusuf M.; Bennett, Stephen J.; Cox, Brian; Davies, Robert J.; Khalaf, Abedawn I.; Waigh, Roger D.; Worsley, Alan J.
Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 4 p. 647 - 659
反应条件
acetic acid; trifluoroacetic acid
5 h; Heating;
参考文献
Lukanov, Ludmil K.; Venkov, Athanas P.; Mollov, Nikola M.
Synthesis, 1987 , # 11 p. 1031 - 1032
反应条件
1: 92 percent / polyphosphoric acid / 12 h / 160 °C
2: 90 percent / Zn; 1,2-dibromoethane; Me3SiCl / acetonitrile / 12 h / 35 - 40 °C
View Scheme
参考文献
Elliott, Mark C.; Williams, Eve
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 17 p. 3038 - 3047
参考文献
Avenarius; Pschorr
Chemische Berichte, 1929 , vol. 62, p. 323
Full Text Show Details
Gulland; Virden
Journal of the Chemical Society, 1929 , p. 1798
