2-氧代-2H-吡喃-5-甲酰氯合成路线 （共 10 条）
反应条件
phosphorus pentachloride T=60°C; 1 h;
参考文献
Rosenmund, Peter; Casutt, Michael; Wittich, Michael
Liebigs Annalen der Chemie, 1990 , p. 233 - 238
反应条件
hydrogen; Pd-BaSO4 in xylene T=110°C; 12 h;
参考文献
Csihony, Szilard; Mika, Laszlo T.; Vlad, Gabor; Barta, Katalin; Mehnert, Christian P.; Horvath, Istvan T.
Collection of Czechoslovak Chemical Communications, 2007 , vol. 72, # 8 p. 1094 - 1106
参考文献
Rosenmund, Peter; Casutt, Michael
Tetrahedron Letters, 1983 , vol. 24, # 17 p. 1771 - 1774
反应条件
amidosulfamic acid 1a) 120 deg C, 1b) 119-120 deg C, 3h;
参考文献
Kvita; Sauter
Helvetica Chimica Acta, 1990 , vol. 73, # 4 p. 883 - 889
反应条件
pyridine in tetrahydrofuran; diethyl ether T=-5 - 25°C; 3 h;
参考文献
Jung, Michael E.; Street, Leslie J.; Usui, Yoshihiro
Journal of the American Chemical Society, 1986 , vol. 108, # 21 p. 6810 - 6811
反应条件
1: 2-Oxo-2H-pyran-5-carboxylic acid With thionyl chloride
1 h;
2: 2-oxo-2H-pyran-5-carbonyl chloride With amidosulfamic acid
T=120°C; 1 h;
3: δ-cyano-α-pyrone With ethylene glycol dimethyl ether; pyridinium tribromide in toluene
4 h; Inert atmsphere;
参考文献
ASTRAZENECA AB
Patent: WO2004/792 A1, 2003 ;
Location in patent: Page 19 ;
反应条件
1: amidosulfamic acid / 1 h / 120 °C
2: pyridinium bromide perbromide / ethylene glycol dimethyl ether; toluene / 4 h / |Inert atmosphere; |Reflux
View Scheme
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
反应条件
1: amidosulfamic acid / 1 h / 120 °C
2: pyridinium bromide perbromide / ethylene glycol dimethyl ether; toluene / 4 h / |Inert atmosphere; |Reflux
3: isopentyl nitrite; trifluoroacetic acid / ethylene glycol dimethyl ether / 0.5 h / |Reflux
View Scheme
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
反应条件
aluminium trichloride
参考文献
Wiley; Slaymaker
Journal of the American Chemical Society, 1956 , vol. 78, p. 2393,2394
反应条件
1.1: amidosulfamic acid / 1 h / 120 °C
2.1: pyridinium bromide perbromide / ethylene glycol dimethyl ether; toluene / 4 h / |Inert atmosphere; |Reflux
3.1: isopentyl nitrite; trifluoroacetic acid / ethylene glycol dimethyl ether / 0.5 h / |Reflux
4.1: hexane; tetrahydrofuran / 0.5 h / -75 °C / |Inert atmosphere
4.2: -75 - -60 °C
View Scheme
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
