3,4-二甲氧基苯磺酰氯合成路线 （共 12 条）
反应条件
chlorosulfonic acid; chloroform
参考文献
Journal of the Chemical Society, , vol. 111, p. 957
参考文献
J. DAVID GLADSTONE INSTITUTES; UNIVERSITY OF MARYLAND
Patent: WO2008/22281 A1, 2008 ;
Location in patent: Page/Page column 59 ;
WO 2008/022281 A2
反应条件
pyridine; hydrogenchloride; sodium hydroxide in ethanol
参考文献
Hoffmann-La Roche Inc.
Patent: US5877193 A1, 1999 ;
反应条件
1: Zn, H2SO4 2: (i) KOH, EtOH, (ii) /BRN= 969135/ View Scheme
参考文献
Jacob III; Anderson III; Meshul; Shulgin; Castagnoli Jr.
Journal of Medicinal Chemistry, 1977 , vol. 20, # 10 p. 1235 - 1239
反应条件
(i) phosphorus, (ii) /BRN= 969135/, NaOEt, EtOH; Multistep reaction;
参考文献
Sucharda-Sobczyk,A.; Syper,L.
Roczniki Chemii, 1975 , vol. 49, p. 749 - 756
反应条件
1,3-dimethyl-imidazolidin-2-one; dimethyl-dichlorosilane; zinc in 1,2-dichloro-ethane T=80°C; 1.5 h;
参考文献
Uchiro, Hiromi; Kobayashi, Susumu
Tetrahedron Letters, 1999 , vol. 40, # 16 p. 3179 - 3182
参考文献
Fries; Koch; Stukenbrock
Justus Liebigs Annalen der Chemie, 1929 , vol. 468, p. 188
反应条件
1: Zn, H2SO4
2: (i) KOH, EtOH, (ii) /BRN= 969135/
3: POCl3
4: NH4OAc
5: LiAlH4 / tetrahydrofuran
View Scheme
参考文献
Jacob III; Anderson III; Meshul; Shulgin; Castagnoli Jr.
Journal of Medicinal Chemistry, 1977 , vol. 20, # 10 p. 1235 - 1239
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/127505 A2, 2007 ;
Location in patent: Page/Page column 39 ;
WO 2007/127505 A2
反应条件
1: 55 percent / triethylamine / tetrahydrofuran / 4 h / Ambient temperature
2: 90 percent / KOH / methanol; H2O
View Scheme
参考文献
Athanasiou; Camoutsis Ch.; Catsoulacos; Christias Ch.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 3 p. 281 - 282
