1: n-ethyl morpholine / acetonitrile / 16.5 h / Heating / reflux 2: hydrogen / palladium 10 on activated carbon / ethanol; water / 6 h / 20 °C / 2250.23 Torr 3: PyAOP / dichloromethane / 3.75 h / 0 - 20 °C 4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C View Scheme

1: n-ethyl morpholine / acetonitrile / 16.5 h / Heating / reflux 2: hydrogen / palladium 10 on activated carbon / ethanol; water / 6 h / 20 °C / 2250.23 Torr 3: PyAOP / dichloromethane / 3.75 h / 0 - 20 °C View Scheme