1: PyAOP / dichloromethane / 3.75 h / 0 - 20 °C 2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C View Scheme

PyAOP in dichloromethane T=0 - 20°C; 3.75 h;

<b>Multi-step reaction with 2 steps<br /> </b>1: n-ethyl morpholine / acetonitrile / 16.5 h / Heating / reflux<br />2: hydrogen / palladium 10 on activated carbon / ethanol; water / 6 h / 20 &deg;C / 2250.23 Torr<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 4-methyl-morpholine; benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 20 h / 0 - 20 &deg;C<br />2: n-ethyl morpholine / acetonitrile / 16.5 h / Heating / reflux<br />3: hydrogen / palladium 10 on activated carbon / ethanol; water / 6 h / 20 &deg;C / 2250.23 Torr<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: sodium carbonate / palladium diacetate; triphenylphosphine / water; acetone / 18 h / Heating / reflux<br />2: n-ethyl morpholine / acetonitrile / 16.5 h / Heating / reflux<br />3: hydrogen / palladium 10 on activated carbon / ethanol; water / 6 h / 20 &deg;C / 2250.23 Torr<br /> <br /> &nbsp;