lithium hydroxide; dihydrogen peroxide in tetrahydrofuran T=0 - 20°C;

1: 97 percent / aq. H2O2; LiOH / tetrahydrofuran / 0 - 20 °C 2: 99 percent / N-(dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; i-Pr2NEt; 1-hydroxy-1,2,3-benzotriazole hydrate / CH2Cl2 / 4 - 20 °C 3: 80 percent / TFA / CH2Cl2 / 2 h / 20 °C View Scheme

1: 97 percent / aq. H2O2; LiOH / tetrahydrofuran / 0 - 20 °C 2: 99 percent / N-(dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; i-Pr2NEt; 1-hydroxy-1,2,3-benzotriazole hydrate / CH2Cl2 / 4 - 20 °C View Scheme