1.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 5 h / -5 - 0 °C / |Inert atmosphere 2.1: ethyl acetate / 18 h / 20 - 40 °C / |Cooling 3.1: [RuCl(p-cumene)((S)-2,2-bis(diphenylphosphino)-1,1-binaphthyl)]chloride; hydrogen / methanol / 40 h / 60 °C / 3102.97 Torr 3.2: 16 h / 20 - 40 °C 4.1: citric acid / dichloromethane; water View Scheme

1.1: [RuCl(p-cumene)((S)-2,2-bis(diphenylphosphino)-1,1-binaphthyl)]chloride; hydrogen / methanol / 40 h / 60 °C / 3102.97 Torr 1.2: 16 h / 20 - 40 °C 2.1: citric acid / dichloromethane; water View Scheme

1: 99 percent / N-(dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; i-Pr2NEt; 1-hydroxy-1,2,3-benzotriazole hydrate / CH2Cl2 / 4 - 20 °C 2: 80 percent / TFA / CH2Cl2 / 2 h / 20 °C View Scheme

1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 - 20 °C 2: trifluoroacetic acid / dichloromethane / 16.25 h / 20 - 25 °C / |Inert atmosphere View Scheme

benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in dichloromethane T=0 - 20°C;