1-[5-(4-吗啉)-2-噻吩]乙酮合成路线 （共 4 条）
反应条件
in dimethyl sulfoxide T=110°C; 48 h;
参考文献
UCB PHARMA S.A.; ALEXANDER, Rikki, Peter; BAILEY, Stuart; BROOKINGS, Daniel, Christopher; BROWN, Julien, Alistair; CALLAGHAN, Sacha; POLLARD, Faye, Charlotte
Patent: WO2010/1126 A1, 2010 ;
Location in patent: Page/Page column 24 ;
WO 2010/001126 A1
反应条件
in water 12 h; Heating;
参考文献
Prim, Damien; Kirsch, Gilbert
Tetrahedron, 1999 , vol. 55, # 21 p. 6511 - 6526
反应条件
in acetonitrile 0.0333333 h; Heating;
参考文献
Hartmann, Horst; Zug, Ines
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 24 p. 4316 - 4320
反应条件
1: acetonitrile / 3 h / Heating 2: Et3N / acetonitrile View Scheme
参考文献
Noack, Antje; Hartmann, Horst
Tetrahedron, 2002 , vol. 58, # 11 p. 2137 - 2146
