potassium carbonate in ethanol; water T=20°C; 24 h;

1: acetic anhydride; acetic acid / 24 h / 20 °C / Inert atmosphere 2: N-iodo-succinimide / tetrahydrofuran / 12 h / 20 °C 3: palladium 10 on activated carbon; hydrogen / ethanol / 6 h / 20 °C 4: sodium hydroxide / ethanol; water 5: human placental alkaline phosphatase; magnesium chloride; zinc(II) chloride / 37 °C / pH 7.4 / aq. buffer; Enzymatic reaction View Scheme