6-氨基苯并[1,3]二氧杂环戊烯-5-甲醛合成路线 （共 11 条）
反应条件
hydrogen in tetrahydrofuran; water T=120°C; P=37503.8 Torr; 15 h; chemoselective reaction;
参考文献
Jagadeesh, Rajenahally V.; Surkus, Annette-Enrica; Junge, Henrik; Pohl, Marga-Martina; Radnik, Joerg; Rabeah, Jabor; Huan, Heming; Schunemann, Volker; Brueckner, Angelika; Beller, Matthias
Science, 2013 , vol. 342, # 6162 p. 1073 - 1076
反应条件
1: 70 percent / nitric acid / 5 - 10 °C 2: 76 percent / iron powder; ammonium chloride / methanol; H2O / 2 h / Heating View Scheme
参考文献
Zhao, Jiuyang; Ling, Xiang; Cao, Shousong; Liu, Xiaojun; Wan, Shengbiao; Jiang, Tao; Li, Fengzhi
Molecular Pharmaceutics, 2014 , vol. 11, # 2 p. 457 - 467
反应条件
toluene-4-sulfonic acid in toluene 8 h; Heating;
参考文献
Wani; Nicholas; Wall
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2358 - 2363
反应条件
toluene-4-sulfonic acid
参考文献
Zalkow,L.N. et al.
Journal of the Chemical Society [Section] C: Organic, 1971 , p. 3551 - 3554
反应条件
sodium hydroxide; silver(l) oxide in water T=55 - 60°C;
参考文献
Mahindroo, Neeraj; Ahmed, Zabeer; Bhagat, Asha; Bedi, Kasturi Lal; Khajuria, Ravi Kant; Kapoor, Vijay Kumar; Dhar, Kanaya Lal
Medicinal Chemistry Research, 2005 , vol. 14, # 6 p. 347 - 368
反应条件
toluene-4-sulfonic acid; acetic acid in toluene
Heating;
参考文献
Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700
反应条件
pyridine
T=55 - 60°C; 0.25 h;
参考文献
Butin, Alexander V.; Smirnov, Sergey K.; Stroganova, Tatyana A.
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 3 p. 623 - 628
反应条件
triethylamine in benzene
0.5 h; Ambient temperature;
参考文献
Lin, Whei Oh; Coutinho, Edson de Souza
Monatshefte fuer Chemie, 1983 , vol. 114, p. 1231 - 1236
反应条件
pyrrolidine; copper(l) iodide in acetonitrile
T=100°C; 12 h; Inert atmosphere;
参考文献
Patil, Nitin T.; Raut, Vivek S.
Journal of Organic Chemistry, 2010 , vol. 75, # 20 p. 6961 - 6964
反应条件
PPh3 gold(I) chloro complex; silver trifluoromethanesulfonate in acetonitrile
T=50°C; 20 h; Inert atmosphere;
参考文献
Patil, Nitin T.; Raut, Vivek S.; Shinde, Valmik S.; Gayatri, Gaddamanugu; Sastry, G. Narahari
Chemistry - A European Journal, 2012 , vol. 18, # 18 p. 5530 - 5535
