5-[4-[3-氯-4-(3-氟苯氧基)苯胺基]-6-喹唑啉基]呋喃-2-甲醛合成路线 （共 28 条）
反应条件
potassium carbonate; palladium diacetate in tetrahydrofuran; ethanol 0.666667 h; Reflux; Product distribution / selectivity;
参考文献
WO2010/17387 A2, ;
Page/Page column 24 ;
反应条件
triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in ethanol 2 h; Heating / reflux;
参考文献
US2008/51422 A1, ;
Page/Page column 13-14 ;
反应条件
palladium 10 on activated carbon; N-ethyl-N,N-diisopropylamine in methanol; ethanol T=90°C; 2.5 h;
参考文献
WO2014/59956 A1, ;
Page/Page column 10; 11 ;
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water T=100°C; 2 h;
参考文献
EP1990337 A1, ;
Page/Page column 18-19 ;
反应条件
palladium 10 on activated carbon; N-ethyl-N,N-diisopropylamine in methanol 8 h; Reflux;
参考文献
WO2014/59956 A1, ;
Page/Page column 9; 10 ;
反应条件
1: 2-formylfuran-5-boronic acid; N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodo-4-quinazolinamine With palladium 10 on activated carbon in ethanol; water 0.0833333 h; 2: With N-ethyl-N,N-diisopropylamine in tetrahydrofuran; ethanol; water T=70°C; 3 h; 3: toluene-4-sulfonic acid in tetrahydrofuran; ethanol; water T=65°C; 0.0833333 h;
参考文献
WO2006/113649 A1, ;
Page/Page column 47 ;
WO 2006/113649 A1
反应条件
1: furfural With n-butyllithium; O,N-dimethyl-hydroxylamine hydrochloride in tetrahydrofuran; hexane T=-20°C; 1.25 h; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexane T=-15°C; 0.25 h; 3: N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodo-4-quinazolinamine With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine in tetrahydrofuran; ethanol; hexane T=60°C; Suzuki coupling;
参考文献
Tetrahedron, , vol. 58, # 9 p. 1657 - 1666
反应条件
1: H2 / Pt/C / ethanol; tetrahydrofuran 2: propan-2-ol / 70 °C 3: Pd(OAc)2; PPh3; Et3N / dimethylformamide View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4686 - 4691
反应条件
1: propan-2-ol / 70 °C 2: Pd(OAc)2; PPh3; Et3N / dimethylformamide View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4686 - 4691
反应条件
1: propan-2-ol / 70 °C 2: Pd(OAc)2; PPh3; Et3N / dimethylformamide View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4686 - 4691
