5-[4-[3-氯-4-(3-氟苯氧基)苯胺基]-6-喹唑啉基]呋喃-2-甲醛合成路线 （共 28 条）
反应条件
1: K2CO3 / acetonitrile 2: H2 / Pt/C / ethanol; tetrahydrofuran 3: propan-2-ol / 70 °C 4: Pd(OAc)2; PPh3; Et3N / dimethylformamide View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4686 - 4691
反应条件
1: K2CO3 / acetonitrile 2: H2 / Pt/C / ethanol; tetrahydrofuran 3: propan-2-ol / 70 °C 4: Pd(OAc)2; PPh3; Et3N / dimethylformamide View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4686 - 4691
反应条件
1: iodine cloride; acetic acid / 3 h / 25 - 35 °C 2: 2 h / 70 - 75 °C 3: acetic acid / 2 h / 115 - 120 °C 4: triethylamine; ethylene glycol dimethyl ether / palladium 10 on activated carbon / methanol / Inert atmosphere View Scheme
反应条件
1: 2 h / 70 - 75 °C 2: acetic acid / 2 h / 115 - 120 °C 3: triethylamine; ethylene glycol dimethyl ether / palladium 10 on activated carbon / methanol / Inert atmosphere View Scheme
反应条件
1: acetic acid / 2 h / 115 - 120 °C 2: triethylamine; ethylene glycol dimethyl ether / palladium 10 on activated carbon / methanol / Inert atmosphere View Scheme
反应条件
1: thionyl chloride / N,N-dimethyl-formamide / Reflux 2: potassium carbonate / N,N-dimethyl-formamide / Reflux 3: triethylamine / bis-triphenylphosphine-palladium(II) chloride / methanol / 2 h / Reflux View Scheme
反应条件
1: acetic acid / xylene / 10 h / Reflux 2: triethylamine / palladium 10 on activated carbon / ethylene glycol dimethyl ether; methanol / 15 h / 45 - 50 °C / Inert atmosphere View Scheme
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: palladium 10 on activated carbon / methanol / 8 h / |Reflux View Scheme
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 0 - 10 °C / Inert atmosphere 2: platinum/carbon xerogel catalyst; hydrogen / tetrahydrofuran 3: 1 h / Heating; Inert atmosphere 4: PdCl2(PPh3)2; sodium carbonate / ethylene glycol dimethyl ether; ethanol; water / 60 °C / Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 24 p. 8546 - 8555
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 0 - 10 °C / Inert atmosphere 2: platinum/carbon xerogel catalyst; hydrogen / tetrahydrofuran 3: 1 h / Heating; Inert atmosphere 4: PdCl2(PPh3)2; sodium carbonate / ethylene glycol dimethyl ether; ethanol; water / 60 °C / Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 24 p. 8546 - 8555
