N,N-二乙基-2-氯乙酰胺合成路线 （共 70 条）
反应条件
1: 75 percent / lithium / tetrahydrofuran / 15 h / Ambient temperature
2: 83 percent / 2 h / 90 - 100 °C
View Scheme
参考文献
Deleris; Dunogues; Babin; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 533 - 537
反应条件
ethanol; acetyl chloride
T=25°C; 17.5 h; Heating / reflux;
参考文献
Teijin Intellectual Property Center Limited; Combichem, Inc.
Patent: US6686353 B1, 2004 ;
Location in patent: Page/Page column 106-107 ;
US 6686353 B1
反应条件
in ethanol; dichloromethane
参考文献
TEIJIN LIMITED
Patent: EP914319 B1, 2001 ;
EP 0914319 B1
反应条件
in acetone
T=70 - 90°C; 8 h;
参考文献
Zhukauskaite, L. N.; Tsybusov, A. P.; Gendenshtein, E. I.; Stankevichyus, A. P.; Tseplene, V. S.; Lubas, A. A.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 6 p. 391 - 396
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 6 p. 43 - 48
反应条件
sodium hydroxide; tetra(n-hexyl)-ammonium chloride in dichloromethane
T=40 - 42°C; 4.5 h; Yield given;
参考文献
Kem, Kenneth M.; Nguyen, Nghi V.; Cross, Dennis J.
Journal of Organic Chemistry, 1981 , vol. 46, p. 5188 - 5192
参考文献
Am.Home Prod.Corp.
Patent: US2676188 , 1950 ;
反应条件
1: tetrahydrofuran / 2 h / 60 °C
2: hydrogen / palladium hydroxide on carbon / methanol / 20 °C / 760.05 Torr
View Scheme
参考文献
TAISHO PHARMACEUTICAL CO., LTD.; MEIJI SEIKA PHARMA CO., LTD.; SUGIMOTO, Tomohiro; SASAMOTO, Naoki; KUROSAKA, Jun; HAYASHI, Masato; YAMAMOTO, Kanako; KASHIMURA, Masato; USHIKI, Yasunobu; OGITA, Haruhisa; MIURA, Tomoaki; KANEMOTO, Kenichi; KUMURA, Kou; YOSHIDA, Satoshi; TAMURA, Keiji; SHITARA, Eiki
Patent: WO2012/115256 A1, 2012 ;
参考文献
Roehnert,H.
Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft, 1960 , vol. 293, p. 573 - 576
反应条件
1: in acetonitrile
26 h; Reflux;
2: With sodium hydroxide in water
0.333333 h; Cooling;
参考文献
Jinks, Michael A.; Sun, Hongmei; Hunter, Christopher A.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 9 p. 1440 - 1447
参考文献
Bayer Aktiengesellschaft
Patent: US4841086 A1, 1989 ;
