1: K2CO3 / H2O / 1 h / Ambient temperature 2: t-BuOK / ethanol / 3 h / Heating 3: 81 percent / H2O2 / H2O / 20 h / 45 °C 4: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h 5: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h 6: 70 percent / KOH / methanol / 7 h / -30 °C 7: 1.) 6N HCl, 2.) Et3N / 1.) 120 deg C, 5 h, 2.) 80 deg C, 2 h View Scheme

1: 94 percent / Et3N 2: 88 percent / m-CPBA View Scheme

1: 1.) K2CO3, 2.) CH3CO3H / 1.) ethylene glycol, glycerol, 105 deg C, 18 h, 2.) AcOH, 20-25 deg C , 1 h 2: 95 percent Chromat. / (1,1,2,3,3,3-hexafluoropropyl)diethylamine (FPA) / CH2Cl2 / 2 h / 100 °C / 5171.5 Torr View Scheme

peracetic acid; potassium carbonate 1.) ethylene glycol, glycerol, 105 deg C, 18 h, 2.) AcOH, 20-25 deg C , 1 h; Yield given. Multistep reaction;