3,5-双(三氟甲基)苯基异硫氰酯合成路线 （共 8 条）
反应条件
1: With 1,4-diaza-bicyclo[2.2.2]octane in toluene T=20°C; 8 h; 2: With bis(trichloromethyl) carbonate in dichloromethane T=-5°C; Reflux;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 9 p. 2923 - 2929
反应条件
triethylamine in tetrahydrofuran T=-10 - 20°C;
参考文献
Synthesis, , # 5 p. 779 - 790
反应条件
1: 1,4-diaza-bicyclo[2.2.2]octane / toluene 2: bis(trichloromethyl) carbonate / dichloromethane View Scheme
参考文献
Medicinal Chemistry Research, , vol. 22, # 8 p. 3959 - 3968
参考文献
Nagarajan, K.; Talwalker, P.K.; Kulkarni, C.L.; Venkateswarlu, A.; Prabhu, S.S.; Nayak, G.V.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1243 - 1257
反应条件
ammonia in ethylene glycol dimethyl ether
参考文献
Synlett, , vol. 23, # 9 p. 1402 - 1406
反应条件
in tetrahydrofuran
T=20°C; 16 h;
参考文献
Berkessel, Albrecht; Mukherjee, Santanu; Mueller, Thomas N.; Cleemann, Felix; Roland, Katrin; Brandenburg, Marc; Neudoerfl, Joerg-M.; Lex, Johann
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 23 p. 4319 - 4330
反应条件
in dichloromethane
T=20°C; 24 h;
参考文献
Marques-Lopez, Eugenia; Alcaine, Ana; Tejero, Tomas; Herrera, Raquel P.
European Journal of Organic Chemistry, 2011 , # 20-21 p. 3700 - 3705
反应条件
1: tert-butyl (S)-1-(N-benzyl-N-methylcarbamoyl)-2,2-dimethylpropylcarbamate With hydrogenchloride in 1,4-dioxane
T=20°C; 2 h;
2: 3,5-bis(trifluoromethyl)phenyl isothiocyanate With triethylamine in dichloromethane
T=20°C; 4 h; Further stages.;
参考文献
Reisman, Sarah E.; Doyle, Abigail G.; Jacobsen, Eric N.
Journal of the American Chemical Society, 2008 , vol. 130, # 23 p. 7198 - 7199
