1-苄基-4-(乙氧基羰基甲基)哌嗪合成路线 （共 8 条）
反应条件
in benzene T=20°C; 2 h;
参考文献
Yuhan Corporation
Patent: US6352993 B1, 2002 ;
Location in patent: Page column 13-14 ;
反应条件
TEA in toluene T=80°C; 7 h;
参考文献
Contreras; Parrot; Sippl; Rival; Wermuth
Journal of Medicinal Chemistry, 2001 , vol. 44, # 17 p. 2707 - 2718
反应条件
potassium carbonate in ethanol; chloroform; water
参考文献
Adir et Compagnie
Patent: US5519023 A1, 1996 ;
反应条件
potassium carbonate in acetone 22 h; Reflux;
参考文献
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; HERGENROTHER, Paul Joseph; PETERSON, Quinn Patrick; HSU, Danny Chung; WEST, Diana C.; FAN, Timothy M.; NOVOTNY, Chris J.
Patent: WO2010/91382 A1, 2010 ;
Location in patent: Page/Page column 31 ;
WO 2010/091382 A1
反应条件
ruthenium trichloride T=20°C; 1.5 h; neat (no solvent);
参考文献
Varala, Ravi; Enugala, Ramu; Adapa, Srinivas R.
Monatshefte fur Chemie, 2008 , vol. 139, # 11 p. 1369 - 1372
反应条件
ethanol; sodium hydrogencarbonate
参考文献
Zaugg et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 2763,2764
反应条件
hydrazine hydrate in ethanol Reflux;
参考文献
Astrand, O. Alexander H.; Aziz, Gulzeb; Ali, Sidra Farzand; Paulsen, Ragnhild E.; Hansen, Trond Vidar; Rongved, Pal
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5175 - 5181
反应条件
sodium hydroxide in methanol T=20°C;
参考文献
Weber, Dirk; Berger, Claudia; Eickelmann, Peter; Antel, Jochen; Kessler, Horst
Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1918 - 1930
