(1R,2S)-(-)-2-氨基-1,2-二苯基乙醇合成路线 （共 45 条）
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; 12 h; atmospheric pressure;
参考文献
Lupattelli, Paolo; Bonini, Carlo; Caruso, Leonilde; Gambacorta, Augusto
Journal of Organic Chemistry, 2003 , vol. 68, # 8 p. 3360 - 3362
反应条件
sodium amalgam; ethanol; acetic acid
参考文献
Chemische Berichte, , vol. 69, p. 861,875
反应条件
1: With thionyl chloride T=-15 - 20°C; Substitution; isomerization; 2: With water Hydrolysis; 3 h; Heating;
参考文献
Lou, Rongliang; Mi, Aiqiao; Jiang, Yaozhong; Qin, Yong; Li, Zhi; Fu, Fangmin; Chan, Albert S.C
Tetrahedron, 2000 , vol. 56, # 32 p. 5857 - 5863
反应条件
1: NaOH / 0.5 h / 60 °C 2: 87 percent / NaN3, H2O / dimethylformamide / 48 h / 110 °C 3: 172.3 g / H2, 6N HCl / Pd/C / ethanol / 40 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 19 p. 3219 - 3222
反应条件
1: MgBr2*Et2O; Amberlyst 15 / acetonitrile / 2 h / 0 °C 2: 95 percent / NaN3 / dimethylformamide / 12 h / 20 °C 3: 95 percent / H2 / 5 percent Pd/C / methanol / 12 h / 20 °C / atmospheric pressure View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 8 p. 3360 - 3362
反应条件
1: 95 percent / NaN3 / dimethylformamide / 12 h / 20 °C 2: 95 percent / H2 / 5 percent Pd/C / methanol / 12 h / 20 °C / atmospheric pressure View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 8 p. 3360 - 3362
反应条件
[14C]-L-Glutamic acid
参考文献
Farmaco, Edizione Scientifica, , vol. 10, p. 673,682
Journal of the American Chemical Society, , vol. 73, p. 1216
反应条件
1: 90 percent / sodium acetate / ethanol / 12 h / Heating 2: 78 percent / BH3*SMe2; (2S,3R)-2-amino-3-(t-BuMe2siloxy)-1,1-diphenylbutanol / 1,2-dimethoxy-ethane / 24 h / 20 °C 3: H2 / Pd-C / ethanol / 25 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 54, # 35 p. 10265 - 10274
反应条件
1: 41.81 g / H2 / 5percent Pd/C / ethanol; H2O / 51 - 52 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 55, # 5 p. 1568 - 1573
反应条件
1: 100 percent / NH2OH*HCl / ethanol; H2O 2: H2 / Pd-C / tetrahydrofuran / 2206.52 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 52 p. 10159 - 10162
