(1R,2S)-(-)-2-氨基-1,2-二苯基乙醇合成路线 （共 45 条）
反应条件
1: ethanol / 3 h / 20 °C 2: NaBH4 / ethanol / 1 h View Scheme
参考文献
Chen, Guoshu; Li, Xin; Zhang, Haile; Gong, Liuzhu; Mi, Aiqiao; Cui, Xin; Jiang, Yaozhong; Choi, Michael C.K.; Chan, Albert S.C.
Tetrahedron Asymmetry, 2002 , vol. 13, # 8 p. 809 - 813
反应条件
reagiert als Hydrochlorid;
参考文献
Read; Campbell
Journal of the Chemical Society, 1930 , p. 2377
Nature (London, United Kingdom), 1930 , vol. 125, p. 16
Full Text Show Details
Read; Steele
Journal of the Chemical Society, 1927 , p. 916 Anm.
反应条件
sodium ethanolate in ethanol; toluene T=90 - 110°C; 7 h; Heating / reflux;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2005/92318 A1, 2005 ;
Location in patent: Page/Page column 41-42 ;
反应条件
sodium acetate; palladium diacetate in acetonitrile T=20°C; P=760 Torr; Electrolysis;
参考文献
Chiarotto, Isabella; Feroci, Marta
Tetrahedron Letters, 2001 , vol. 42, # 20 p. 3451 - 3453
反应条件
1: With N(Et)4(1+)*(2-pyrrolidone-anion) in acetonitrile T=20°C; Carboxylation; 1 h; 2: With p-toluenesulfonyl chloride in acetonitrile T=20°C; Cyclization; Further stages.;
参考文献
Casadei, M. Antonietta; Feroci, Marta; Inesi, Achille; Rossi, Leucio; Sotgiu, Giovanni
Journal of Organic Chemistry, 2000 , vol. 65, # 15 p. 4759 - 4761
反应条件
triethylamine in dichloromethane T=0°C;
参考文献
Begis, Guillaume; Sheppard, Tom D.; Cladingboel, David E.; Motherwell, William B.; Tocher, Derek A.
Synthesis, 2005 , # 19 art. no. C06405SS, p. 3186 - 3188
反应条件
1: in acetonitrile T=20°C; Acylation; 2 h; 2: With p-toluenesulfonyl chloride in acetonitrile T=25°C; Cyclization; 10 h;
参考文献
Feroci, Marta; Inesi, Achille; Mucciante, Vittoria; Rossi, Leucio
Tetrahedron Letters, 1999 , vol. 40, # 33 p. 6059 - 6060
反应条件
1: (1R,2S)-(-)-2-Amino-1,2-diphenylethanol in acetonitrile T=20°C; Electrolysis; 2: carbon dioxide 1 h; 3: p-toluenesulfonyl chloride T=20°C;
参考文献
Tetrahedron Letters, , vol. 43, # 33 p. 5863 - 5865
反应条件
1: 94 percent / Na2CO3 / tetrahydrofuran; H2O / 3 h / 0 °C 2: SO2Cl2; 2,4,6-collidine / CH2Cl2 / 1 h / -45 °C 3: 83 percent / tetrahydrofuran / -45 °C 4: 91 percent / Fe(NO3)3*9H2O; NH3; Li / 0.5 h / -78 °C View Scheme
参考文献
Arnum, Susan D. Van; Carpenter, Barry K.; Parrish, David R.; MacIntrye, Archibald
Journal of Organic Chemistry, 2004 , vol. 69, # 24 p. 8533 - 8536
反应条件
sodium hydroxide in toluene
参考文献
Nohira, Hiroyuki; Mizuguchi, Keiko; Murata, Toru; Yazaki, Yuko; Kanazawa, Miho; Aoki, Yoshio; Nohira, Misako
Heterocycles, 2000 , vol. 52, # 3 p. 1359 - 1370
