3-氨基-2-喹噁啉甲腈 1,4-二氧化物合成路线 （共 12 条）
反应条件
tert.-butylnitrite in N,N-dimethyl-formamide
T=65 - 70°C; 2 h;
参考文献
Monge; Martinez-Crespo; De Cerain; Palop; Narro; Senador; Marin; Sainz; Gonzalez; Hamilton; Barker
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4488 - 4494
反应条件
1: 2.) sodium ditionate / 1.) methanol, 50 deg C, 2 h, 2.) ethanol, water, 50 deg C, 3 h
2: 1.) 35percent HCl, acetic acid, 2.) sodium nitrite / 1.) 4 deg C, 20 min, 2.) water, RT, 6 h
3: 90 percent / hydrazine hydrate / 1 h / Heating
View Scheme
参考文献
Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139
