1-甲烷磺酰基-2-甲苯合成路线 （共 17 条）
反应条件
(i) aq. NaOH, NaHCO3, (ii) /BRN= 969135/, EtOH; Multistep reaction;
参考文献
Kugita,H. et al.
Chemical and Pharmaceutical Bulletin, 1962 , vol. 10, p. 1001 - 1008
反应条件
1: (i) NaNO2, aq. H2SO4, (ii) SO2, Cu 2: (i) Na2CO3, (ii) /BRN= 969135/, EtOH View Scheme
参考文献
Eistert,B. et al.
Chemische Berichte, 1964 , vol. 97, p. 1470 - 1481
反应条件
(i) Na2CO3, (ii) /BRN= 969135/, EtOH; Multistep reaction;
参考文献
Eistert,B. et al.
Chemische Berichte, 1964 , vol. 97, p. 1470 - 1481
反应条件
bromine T=180°C; Irradiation;
参考文献
Journal of the Chemical Society, , p. 1420 - 1427
反应条件
sulfuric acid; acetic anhydride 1.) from 0 to 10 deg C, 2 h, 2.) aq. EtOH, reflux, 0.5 h; Yield given. Multistep reaction;
参考文献
Sivasubramanian, S; Ravichandran, K
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 12 p. 1148 - 1149
反应条件
1.1: n-BuLi / tetrahydrofuran / 1.5 h / 20 °C
1.2: 92 percent / tetrahydrofuran / 1 h / 0 °C
2.1: 87 percent / triethylamine; p-toluenesulfonyl azide / acetonitrile / 8 h / 20 °C
View Scheme
参考文献
Takeda, Hiroyuki; Nakada, Masahisa
Tetrahedron Asymmetry, 2006 , vol. 17, # 20 p. 2896 - 2906
反应条件
1: methyl 2-methylphenyl sulphone With n-butyllithium in tetrahydrofuran
T=20°C; 1.5 h;
2: pent-4-enoic acid ethyl ester in tetrahydrofuran
T=0°C; 1 h;
参考文献
Takeda, Hiroyuki; Nakada, Masahisa
Tetrahedron Asymmetry, 2006 , vol. 17, # 20 p. 2896 - 2906
