6,7-二甲氧基-1,2,3,4-四氢异喹啉盐酸盐合成路线 （共 14 条）
反应条件
hydrogenchloride in water; isopropyl alcohol T=20°C; 18 h;
参考文献
US2008/33177 A1, ;
Page/Page column 10-11 ;
反应条件
hydrogenchloride in ethanol Pictet-Spengler reaction;
参考文献
Zhu, Ju; Lu, Jiaguo; Zhou, Youjun; Li, Yaowu; Cheng, Jun; Zheng, Canhui
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 20 p. 5285 - 5289
反应条件
hydrogenchloride in water 8 h; Heating;
参考文献
Stenlake; Waigh; Urwin; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 508 - 514
反应条件
in ethanol; water addn. of 5percent aq. HCl to the ethanol soln. (cooling, stirring), stirring for 30min, refluxing for 30min;;
参考文献
Chem. Pharm. Bull. (Tokyo), , vol. 14, p. 1382 - 1388
B: B-Verb.14, 3.14.1, page 144 - 145
反应条件
hydrogen bromide T=120°C; 2 h;
参考文献
RESPIRATORIUS AB
Patent: WO2008/95852 A1, 2008 ;
Location in patent: Page/Page column 38 ;
参考文献
Ortho Pharmaceutical Corporation
Patent: US5066658 A1, 1991 ;
US 5066658 A
反应条件
sodium hydrogencarbonate in water 0.5 h;
参考文献
INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY; LEE, Keesook; SONG, Chin-Hee; CHO, Won-Jea
Patent: WO2010/143803 A2, 2010 ;
Location in patent: Page/Page column 22 ;
WO 2010/143803 A2
反应条件
nickel sulphate; sodium hydroxide; dipotassium peroxodisulfate in dichloromethane; water 1 h; Ambient temperature;
参考文献
Chemistry Letters, , # 5 p. 823 - 826
反应条件
potassium carbonate; sodium iodide in N,N-dimethyl-formamide T=100°C; 12 h; Industry scale;
参考文献
HANMI SCIENCE CO., LTD
Patent: US2012/330020 A1, 2012 ;
Location in patent: Page/Page column 7 ;
反应条件
1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 12 h / 100 °C / Industry scale 2: hydrogenchloride; iron / ethanol; water / 4 h / 80 °C / Industry scale View Scheme
参考文献
HANMI SCIENCE CO., LTD
Patent: US2012/330020 A1, 2012 ;
