6,7-二甲氧基-1,2,3,4-四氢异喹啉盐酸盐合成路线 （共 14 条）
反应条件
hydrogen bromide; sodium carbonate in water; acetone
参考文献
Xenova Limited
Patent: US6218393 B1, 2001 ;
US 6218393 B1
反应条件
1: 1,2,3,4-Tetrahydro-6,7-dimethoxyisoquinoline hydrochloride With triethylamine in ethanol T=20°C; 1 h; Inert atmosphere; 2: benzyl bromide in ethanol T=20°C; 3.5 h; Inert atmosphere;
参考文献
Luethy, Monique; Darmency, Vincent; Renaud, Philippe
European Journal of Organic Chemistry, 2011 , # 3 p. 547 - 552
反应条件
1: 1,2,3,4-Tetrahydro-6,7-dimethoxyisoquinoline hydrochloride With sodium hydroxide in dichloromethane; water
Inert atmosphere;
2: formaldehyd With formic acid in water
T=100°C; Inert atmosphere;
参考文献
Luethy, Monique; Darmency, Vincent; Renaud, Philippe
European Journal of Organic Chemistry, 2011 , # 3 p. 547 - 552
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile
T=20°C; 4 h; Inert atmosphere;
参考文献
Ho, Sherman Si Han; Go, Mei Lin
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 22 p. 6127 - 6133
