2-羟基-3-甲基苯甲酸甲酯合成路线 （共 36 条）
反应条件
1: H2SO4; acetic acid / 95 °C 2: aq. NaOH / dioxane / 80 °C View Scheme
参考文献
Shrestha, Suja; Bhattarai, Bharat Raj; Chang, Kyung Ja; Lee, Keun-Hyeung; Cho, Hyeongjin
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 10 p. 2760 - 2764
参考文献
Xing, Man; Zhao, Ting-Ting; Ren, Yu-Jia; Peng, Na-Na; Yang, Xian-Hui; Li, Xi; Zhang, Hui; Liu, Gao-Qi; Zhang, Li-Rong; Zhu, Hai-Liang
Medicinal Chemistry Research, 2014 , vol. 23, # 7 p. 3274 - 3286
反应条件
hydrogenchloride; sodium hydroxide in N-methyl-acetamide
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4284644 A1, 1981 ;
参考文献
Raikow; Tischkow
Chemiker-Zeitung, Chemische Apparatur, 1905 , vol. 29, p. 1269
参考文献
Raikow; Tischkow
Chemiker-Zeitung, Chemische Apparatur, 1905 , vol. 29, p. 1269
反应条件
pyridine; n-butyllithium; trifluoromethylsulfonic anhydride in tetrahydrofuran; dichloromethane; toluene
参考文献
Novartis AG
Patent: US6197798 B1, 2001 ;
参考文献
Anschuetz
Justus Liebigs Annalen der Chemie, 1924 , vol. 439, p. 10
参考文献
Raikow; Tischkow
Chemiker-Zeitung, Chemische Apparatur, 1905 , vol. 29, p. 1269
反应条件
1: 59 percent / sodium hydride / dimethylformamide / 2 h / 80 °C
2: 53 percent / triethylene glycol dimethyl ether / 24 h / Heating
3: 56 percent / sodium hydroxide / methanol; H2O / 8 h / Heating
View Scheme
参考文献
Liepa, Andris J.; Nguyen, Oanh; Saubern, Simon
Australian Journal of Chemistry, 2005 , vol. 58, # 12 p. 864 - 869
反应条件
1: sodium iodide; sodium hydroxide; aq. sodium hypochlorite / methanol / 4.5 h / 0 - 3 °C
2: 84 percent / hydroxylamine hydrochloride; potassium hydroxide / methanol / 6 h / Heating
View Scheme
参考文献
Deng, Bo-Liang; Hartman, Tracy L.; Buckheit Jr., Robert W.; Pannecouque, Christophe; De Clercq, Erik; Fanwick, Phillip E.; Cushman, Mark
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 6140 - 6155
