2-羟基-3-甲基苯甲酸甲酯合成路线 （共 36 条）
反应条件
1: 65 percent / BuLi / tetrahydrofuran / 3 h / 60 °C
2: 56 percent / acetic anhydride, pyridine / toluene / 5 h / Heating
3: 80 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 6 h / Heating; Irradiation
View Scheme
参考文献
Zammattio, F.; Brion, J. D.; Belachmi, L.; Le Baut, G.
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 8 p. 2013 - 2019
反应条件
1: 65 percent / BuLi / tetrahydrofuran / 3 h / 60 °C
2: 56 percent / acetic anhydride, pyridine / toluene / 5 h / Heating
3: 80 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 6 h / Heating; Irradiation
4: 52 percent / Ambient temperature
View Scheme
参考文献
Zammattio, F.; Brion, J. D.; Belachmi, L.; Le Baut, G.
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 8 p. 2013 - 2019
反应条件
1: 65 percent / BuLi / tetrahydrofuran / 3 h / 60 °C
2: 56 percent / acetic anhydride, pyridine / toluene / 5 h / Heating
3: 80 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 6 h / Heating; Irradiation
4: 52 percent / Ambient temperature
5: 96 percent / conc. H2SO4 / acetic acid; H2O / 4 h / Heating
View Scheme
参考文献
Zammattio, F.; Brion, J. D.; Belachmi, L.; Le Baut, G.
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 8 p. 2013 - 2019
反应条件
1: 76 percent / conc. H2SO4 / 72 h / Ambient temperature
2: 43 percent / NBS, benzoyl peroxide / CCl4 / 5 h / Heating; Irradiation
3: benzene / 48 h / Ambient temperature
4: n-BuLi / hexane; tetrahydrofuran / 2 h / Ambient temperature
View Scheme
参考文献
Filler, Robert; Lin, Shan; Zhang, Zhaoxu
Journal of Fluorine Chemistry, 1995 , vol. 74, p. 69 - 76
反应条件
1: sodium iodide; sodium hydroxide; aq. sodium hypochlorite / methanol / 4.5 h / 0 - 3 °C
2: 7.69 g / tetrabutylammonium bromide; aq. sodium hydroxide / CH2Cl2 / 20 °C
View Scheme
参考文献
Xu; Loftus; Wargo; Turpin; Buckheit Jr.; Cushman
Journal of Organic Chemistry, 2001 , vol. 66, # 18 p. 5958 - 5964
反应条件
1: 3-methylsalicylic acid methyl ester With potassium carbonate in N,N-dimethyl-formamide
0.75 h; Inert atmosphere;
2: methyl iodide in N,N-dimethyl-formamide
Inert atmosphere;
参考文献
Dean, Melissa A.; Hitchcock, Shawn R.
Tetrahedron Asymmetry, 2010 , vol. 21, # 20 p. 2471 - 2478
