2-(5-甲氧基-1H-吲哚-3-基)乙酸甲酯合成路线 （共 10 条）
反应条件
sulfuric acid 2 h; Heating;
参考文献
Sintas, Jose A.; Vitale, Arturo A.
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 8 p. 677 - 684
反应条件
potassium carbonate in N,N-dimethyl-formamide T=0 - 20°C; 2 h;
参考文献
GRUeNENTHAL GMBH; FRANK, Robert; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo
Patent: WO2012/62462 A1, 2012 ;
Location in patent: Page/Page column 82 ;
反应条件
sodium hypophosphite; 2-methyl propanoic acid; palladium on activated charcoal in 1,4-dioxane; water T=20°C; 48 h;
参考文献
Kai, Kenji; Horita, Junko; Wakasa, Kyo; Miyagawa, Hisashi
Phytochemistry, 2007 , vol. 68, # 12 p. 1651 - 1663
反应条件
1: tetrahydrofuran / 2 h / 0 °C 2: triethylamine / tetrahydrofuran / 4 h / 20 °C 3: 94 percent / NaH2PO2*H2O / palladium on activated charcoal / dioxane; H2O / 48 h / 20 °C View Scheme
参考文献
Kai, Kenji; Horita, Junko; Wakasa, Kyo; Miyagawa, Hisashi
Phytochemistry, 2007 , vol. 68, # 12 p. 1651 - 1663
反应条件
1: triethylamine / tetrahydrofuran / 4 h / 20 °C 2: 94 percent / NaH2PO2*H2O / palladium on activated charcoal / dioxane; H2O / 48 h / 20 °C View Scheme
参考文献
Kai, Kenji; Horita, Junko; Wakasa, Kyo; Miyagawa, Hisashi
Phytochemistry, 2007 , vol. 68, # 12 p. 1651 - 1663
反应条件
1: 20percent KOH / H2O / 5 h / Heating 2: 10 N HCl / 2 h / Heating View Scheme
参考文献
Morales-Rios, Martha S.; Santos-Sanchez, Norma F.; Suarez-Castillo, Oscar R.; Joseph-Nathan, Pedro
Journal of Organic Chemistry, 2003 , vol. 68, # 2 p. 305 - 311
反应条件
1: 82 percent / H2O / 40 h / 20 °C 2: 75 percent / LiAlH4 / CH2Cl2; tetrahydrofuran / 9 h / Heating 3: 60 percent / aq. HBr View Scheme
参考文献
Sintas, Jose A.; Vitale, Arturo A.
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 8 p. 677 - 684
反应条件
potassium hydroxide in tetrahydrofuran; water T=20°C;
参考文献
Kai, Kenji; Horita, Junko; Wakasa, Kyo; Miyagawa, Hisashi
Phytochemistry, 2007 , vol. 68, # 12 p. 1651 - 1663
反应条件
lithium borohydride in methanol; diethyl ether T=20°C;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 24 p. 6810 - 6822
反应条件
1: 82 percent / H2O / 40 h / 20 °C 2: 75 percent / LiAlH4 / CH2Cl2; tetrahydrofuran / 9 h / Heating View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 39, # 8 p. 677 - 684
