四氢-4-甲基-2H-吡喃-4-羧酸合成路线 (共 2 条)
反应条件
1: 3,4,5,6-Tetrahydro-2H-pyran-4-carboxylic acid With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=0 - 50°C; 3.41667 h; 2: methyl iodide in tetrahydrofuran; hexane T=0 - 20°C; 3: With water; citric acid in tetrahydrofuran; hexane
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/37293 A1, 2009 ;
Location in patent: Page/Page column 53 ;
WO 2009/037293 A1
反应条件
sodium hydroxide in water T=20°C; 24 h;
参考文献
ChemMedChem, , vol. 5, # 1 p. 65 - 78