(R)-(-)-1,2,3,4-四氢-1-萘酚合成路线 （共 59 条）
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / diethyl ether 2: sodium carbonate / toluene / 72 h / 40 °C / Enzymatic reaction View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 23, # 11-12 p. 828 - 833
反应条件
lipase Amano PS30 in various solvent(s) Enzymatic reaction;
参考文献
Merlic; Walsh
Journal of Organic Chemistry, 2001 , vol. 66, # 7 p. 2265 - 2274
反应条件
in hexane Acylation; isobutylation; 18 h; Heating; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 64, # 26 p. 9365 - 9373
反应条件
in benzene T=35°C; 2.5 h; Irradiationporcine pancreas lipase-catalyzed; microwave irradiation; ee investigated; Rate constantProduct distribution;
参考文献
Tetrahedron Letters, , vol. 39, # 24 p. 4333 - 4336
反应条件
in benzene 2.5 h; HeatingIrradiationporcine pancreas lipase-catalyzed; microwave irradiation; ee investigated; Rate constantProduct distribution;
参考文献
Tetrahedron Letters, , vol. 39, # 24 p. 4333 - 4336
反应条件
Lactobacillus kefir alcohol dehydrogenase; tris(hydroxymethyl)methylamine hydrochloride; NADPH in water T=30°C; pH=7; 0.25 h; aq. bufferEnzymatic reaction;
参考文献
Endo, Satoshi; Matsunaga, Toshiyuki; Matsumoto, Atsuko; Arai, Yuki; Ohno, Satoshi; El-Kabbani, Ossama; Tajima, Kazuo; Bunai, Yasuo; Yamano, Shigeru; Hara, Akira; Kitade, Yukio
Biochemical Pharmacology, 2013 , vol. 86, # 9 p. 1366 - 1375
反应条件
perchloric acid in water T=25°C; racemisation; Rate constant;
参考文献
Kelly, Sandra C.; McDonnell, Claire A.; O'Ferrall, Rory A. More; Rao, S. Nagaraja; Boyd, Derek R.; et al.
Gazzetta Chimica Italiana, 1996 , vol. 126, # 11 p. 747 - 754
反应条件
1: With diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene in toluene T=0 - 20°C; Azidation; 18 h; 2: With lithium aluminium tetrahydride in tetrahydrofuran Reduction; 2 h; 3: With sodium hydroxide Hydrolysis; Further stages.;
参考文献
Roever, Stephan; Adam, Geo; Cesura, Andrea M.; Galley, Guido; Jenck, Francois; Monsma Jr., Frederick J.; Wichmann, Juergen; Dautzenberg, Frank M.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 7 p. 1329 - 1338
反应条件
oxalyl dichloride; Bis-lt;(p-methoxy)phenylgt;cyclopropenon in dichloromethane
T=30°C; 1 h; Inert atmosphere;
参考文献
Vanos, Christine M.; Lambert, Tristan H.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 51 p. 12222 - 12226
