(R)-(-)-1,2,3,4-四氢-1-萘胺合成路线 （共 17 条）
反应条件
pyridoxal 5'-phosphate; recombinant ω-transaminase from Burkholderia vietnamiensis G4 in aq. buffer T=37°C; pH=7.4; 12 h; Resolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 100, p. 32 - 39
反应条件
hydrogen; acetic acid; palladium on activated charcoal in methanol P=3040 Torr; 24 h;
参考文献
Tetrahedron Asymmetry, , vol. 9, # 24 p. 4369 - 4379
反应条件
water; triphenylphosphine in tetrahydrofuran 2 h; Reflux;
参考文献
EP2128154 A1, ;
Page/Page column 16 ;
EP 2128154 A1
反应条件
1: 4 Angstroem molecular sieves / benzene / 24 h / Ambient temperature 2: 1.) H2, PtO2, 2.) NaIO4 / 1.) C6H6, 2.) CH3OH, RT, 5 h View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 4, # 9 p. 2095 - 2100
反应条件
hydrogenchloride; (+)-ketopinic acid; water; lithium diisopropyl amide Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron: Asymmetry, , vol. 5, # 5 p. 817 - 820
反应条件
1: With (Ph)2SiH2; silver trifluoromethanesulfonate in ethylene glycol dimethyl ether T=20°C; 25 h; 2: With hydrogenchloride in methanol; ethylene glycol dimethyl ether Further stages. Title compound not separated from byproducts.;
参考文献
Chemical Communications, , # 22 p. 2360 - 2361
反应条件
sodium tetrahydroborate; (S)-valinol; zirconium tetrachloride in tetrahydrofuran Ambient temperature; Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 7 p. 1859 - 1863
反应条件
1: 80 percent / 4 Angstroem molecular sieves; Rh2[(S)-nttl]4; bis(tert-butylcarbonyloxy)iodobenzene / 1,1,2,2-tetrachloro-ethane; methanol / 72 h / -35 °C 2: Na; naphthalene / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 45, # 28 p. 4641 - 4644
反应条件
1: With diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene in toluene T=0 - 20°C; Azidation; 18 h; 2: With lithium aluminium tetrahydride in tetrahydrofuran Reduction; 2 h; 3: With sodium hydroxide Hydrolysis; Further stages.;
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 7 p. 1329 - 1338
