(R)-(-)-1,2,3,4-四氢-1-萘胺合成路线 （共 17 条）
反应条件
coated protease in 3-methyl pentan-3-ol T=21°C; 456 h; Resolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 9 p. 1759 - 1764
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 8 p. 1558 - 1566
反应条件
1.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 5 h / Reflux 2.1: sodium hydride / N,N-dimethyl-formamide / 24 h / Cooling with ice 2.2: 20 °C 3.1: C9H16BNO / tetrahydrofuran / 24 h / 20 °C 3.2: 24 h / Reflux View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 23, # 9 p. 716 - 721
反应条件
N,N'-dimethyl-N,N'-propyleneurea T=-20°C; 24 h; Title compound not separated from byproducts;
参考文献
Angewandte Chemie - International Edition, , vol. 43, # 25 p. 3314 - 3317
反应条件
1: R-1-amino-1,2,3,4-tetrahydronaphthalene With n-butyllithium; chloro-trimethyl-silane in diethyl ether T=0°C; Inert atmosphere; 2: chloro-diphenylphosphine in diethyl ether T=-25°C;
参考文献
Qiu, Min; Hu, Xiang-Ping; Huang, Jia-Di; Wang, Dao-Yong; Deng, Jun; Yu, Sai-Bo; Duan, Zheng-Chao; Zheng, Zhuo
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 17 p. 2683 - 2689
反应条件
1: sodium tris(acetoxy)borohydride / dichloromethane; isopropyl alcohol / 2 h / 20 °C / |Inert atmosphere 2: sodium tris(acetoxy)borohydride / dichloromethane; isopropyl alcohol / 2 h / 20 °C / |Inert atmosphere 3: palladium on activated charcoal; methanol / ethyl acetate / 2 h / 1551.49 Torr / |Inert atmosphere View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BORZILLERI, Robert M.; PEREZ, Heidi L.; WEI, Donna D.; KIM, Kyoung S.
Patent: WO2014/25759 A1, 2014 ;
