(S)-(+)-1,2,3,4-四氢-1-萘胺合成路线 （共 22 条）
反应条件
1: With diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene in toluene T=0 - 20°C; Azidation; 18 h; 2: With lithium aluminium tetrahydride in tetrahydrofuran Reduction; 2 h; 3: With sodium hydroxide Hydrolysis; Further stages.;
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 7 p. 1329 - 1338
反应条件
Candida antarctica lipase B in di-isopropyl ether T=60°C;
参考文献
Skupinska, Krystyna A.; McEachern, Ernest J.; Baird, Ian R.; Skerlj, Renato T.; Bridger, Gary J.
Journal of Organic Chemistry, 2003 , vol. 68, # 9 p. 3546 - 3551
反应条件
Novozym® 435 (lipase B from C. antarctica, recombinant, expressed in Aspergillus niger, adsorbed on acrylic resin) in toluene T=0 - 70°C; Flow reactorEnzymatic reaction; Kinetics; TemperatureReagent/catalyst; stereoselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 85-86, p. 119 - 125
反应条件
1: 85 percent / NaBH4+tetrahydrofurfuryl alcohol / (S,S)-Co(II) complex catalyst (C46H50N2O4Co) / ethanol; CHCl3 / 4 h / 0 °C 2: 85 percent / HCl / methanol / 3 h / 25 °C View Scheme
参考文献
Chemistry Letters, , # 6 p. 493 - 494
反应条件
coated protease in 3-methyl pentan-3-ol T=21°C; 456 h; Resolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 9 p. 1759 - 1764
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 8 p. 1558 - 1566
反应条件
1.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 5 h / Reflux 2.1: sodium hydride / N,N-dimethyl-formamide / 24 h / Cooling with ice 2.2: 20 °C 3.1: C9H16BNO / tetrahydrofuran / 24 h / 20 °C 3.2: 24 h / Reflux View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 23, # 9 p. 716 - 721
反应条件
N,N'-dimethyl-N,N'-propyleneurea T=-20°C; 24 h; Title compound not separated from byproducts;
参考文献
Angewandte Chemie - International Edition, , vol. 43, # 25 p. 3314 - 3317
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Chemical Communications, , # 2 p. 173 - 174
反应条件
pyridoxal 5'-phosphate; recombinant ω-transaminase from Burkholderia vietnamiensis G4 in aq. phosphate buffer T=37°C; pH=7.4; 0.0833333 h; Enzymatic reaction; enantioselective reaction;
参考文献
Jiang, Jinju; Chen, Xi; Feng, Jinhui; Wu, Qiaqing; Zhu, Dunming
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 100, p. 32 - 39
