N-[(1,1-二甲基乙氧基)羰基]-L-缬氨酰-L-脯氨酸合成路线 （共 13 条）
反应条件
lithium hydroxide in methanol; water T=25°C; 2 h;
参考文献
Boruah, Anima; Rao, I. Nageshwar; Nandy, Jyoti Prokash; Kumar, S. Kiran; Kunwar; Iqbal, Javed
Journal of Organic Chemistry, 2003 , vol. 68, # 12 p. 5006 - 5008
反应条件
1: t-Boc-L-valine With chloroformic acid ethyl ester; triethylamine in tetrahydrofuran T=0 - 20°C; 2: L-proline in tetrahydrofuran T=0 - 20°C;
参考文献
CADILA PHARMACEUTICALS LTD.; KHAMAR, Bakulesh Mafatlal; CHANDAN, Singh; MODI, Rajiv, Indravadan
Patent: WO2010/29422 A1, 2010 ;
Location in patent: Page/Page column 8 ;
WO 2010/029422 A1
反应条件
triethylamine in tetrahydrofuran; water T=20°C;
参考文献
Ganellin, C. Robin; Bishop, Paul B.; Bambal, Ramesh B.; Chan, Suzanne M. T.; Law, James K.; Marabout, Benoit; Luthra, Pratibha Mehta; Moore, Andrew N. J.; Peschard, Olivier; Bourgeat, Pierre; Rose, Christiane; Vargas, Froylan; Schwartz, Jean-Charles
Journal of Medicinal Chemistry, 2000 , vol. 43, # 4 p. 664 - 674
反应条件
sodium hydroxide in methanol T=20°C; 2 h;
参考文献
Linge Gowda; Kumara; Channe Gowda; Rangappa
International Journal of Chemical Kinetics, 2006 , vol. 38, # 6 p. 376 - 385
反应条件
1: 81.2 percent / HOBt; EDCI / dimethylformamide / 20 °C 2: 93.5 percent / aq. NaOH / methanol / 2 h / 20 °C View Scheme
参考文献
International Journal of Chemical Kinetics, , vol. 38, # 6 p. 376 - 385
反应条件
1: 92 percent / EDC; HOBt; N,N-diisopropylethylamine / CH2Cl2 2: aq. LiOH / dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 3 p. 793 - 797
反应条件
1: CDI / CH2Cl2 / 16 h / Ambient temperature 2: 1 N aq. KOH / ethanol / 16 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 4 p. 641 - 662
参考文献
Tantry, Subramanyam J.; Babu, Vommina V. Suresh
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 6 p. 1282 - 1287
反应条件
1.1: 68 percent / NaOH / H2O / 3 h 2.1: isobutyl chloroformate; triethylamine / CH2Cl2 / 0.02 h / 0 °C 2.2: 31 percent / triethylamine / CH2Cl2 / 25 °C 3.1: 84 percent / lithium hydroxide monohydrate / methanol; H2O / 2 h / 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 12 p. 5006 - 5008
反应条件
1.1: 68 percent / NaOH / H2O / 3 h 2.1: isobutyl chloroformate; triethylamine / CH2Cl2 / 0.02 h / 0 °C 2.2: 31 percent / triethylamine / CH2Cl2 / 25 °C 3.1: 84 percent / lithium hydroxide monohydrate / methanol; H2O / 2 h / 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 12 p. 5006 - 5008
