(1S,2R)-2-氨基-1,2-二苯基乙醇合成路线 （共 40 条）
反应条件
1: 1.) sodium bis(trimethylsilyl)amide, (+)-(2R,8aS)-(camphorylsulfonyl)oxaziridine / 1.) THF, -78 deg C, 45 min, 2.) reflux, 2 h 2: 5percent NaOH / CH2Cl2 / 0.75 h / 5 °C 3: hyroxylamine hydrochloride, sodium acetate / ethanol; H2O / 0.33 h / Heating 4: 69 percent / H2, 1.5percent HCl / 5percent Pd/C / ethanol / 7 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 54, # 8 p. 2021 - 2024
反应条件
1: hyroxylamine hydrochloride, sodium acetate / ethanol; H2O / 0.33 h / Heating 2: 69 percent / H2, 1.5percent HCl / 5percent Pd/C / ethanol / 7 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 54, # 8 p. 2021 - 2024
反应条件
1: 5percent NaOH / CH2Cl2 / 0.75 h / 5 °C 2: hyroxylamine hydrochloride, sodium acetate / ethanol; H2O / 0.33 h / Heating 3: 69 percent / H2, 1.5percent HCl / 5percent Pd/C / ethanol / 7 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 54, # 8 p. 2021 - 2024
反应条件
1: 90 percent / sodium acetate / ethanol / 12 h / Heating 2: 78 percent / BH3*SMe2; (2S,3R)-2-amino-3-(t-BuMe2siloxy)-1,1-diphenylbutanol / 1,2-dimethoxy-ethane / 24 h / 20 °C 3: H2 / Pd-C / ethanol / 25 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 54, # 35 p. 10265 - 10274
反应条件
1: 41.81 g / H2 / 5percent Pd/C / ethanol; H2O / 51 - 52 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 55, # 5 p. 1568 - 1573
反应条件
sodium hydroxide in water T=70°C;
参考文献
Li, Xinyao; Chen, Ning; Xu, Jiaxi
Synthesis, 2010 , # 20 art. no. F08810SS, p. 3423 - 3428
反应条件
nickel in ethanol 2 h;
参考文献
Organic Letters, , vol. 5, # 23 p. 4513 - 4516
反应条件
1.1: TFA / methanol / 0.25 h / 0 °C 1.2: 70 percent / aq. HCl / methanol / 1 h 2.1: 68 percent / Raney nickel / tetrahydrofuran / 2 h View Scheme
参考文献
Tetrahedron, , vol. 62, # 36 p. 8525 - 8532
反应条件
1: methanol / |Resolution of racemate 2: ammonium hydroxide / water / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 18 p. 9309 - 9316
反应条件
1: hydroxylamine hydrochloride; sodium acetate / water / 3 h / |Inert atmosphere 2: triethylamine / dichloromethane; hexane / 15 h / -40 - 20 °C / |Inert atmosphere 3: potassium carbonate; sodium iodide; (S)-(+)-2-((benzyloxy)diphenylmethyl)tetrahydrothiophene / acetonitrile / 48 h / |Inert atmosphere; |Schlenk technique 4: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere 5: trifluoroacetic acid / water; acetone / 10 - 20 °C / |Inert atmosphere View Scheme
参考文献
Chemical Communications, , vol. 50, # 9 p. 1101 - 1103
