(1S,2R)-2-氨基-1,2-二苯基乙醇合成路线 （共 40 条）
反应条件
1: potassium carbonate; sodium iodide; (S)-(+)-2-((benzyloxy)diphenylmethyl)tetrahydrothiophene / acetonitrile / 48 h / |Inert atmosphere; |Schlenk technique 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere 3: trifluoroacetic acid / water; acetone / 10 - 20 °C / |Inert atmosphere View Scheme
参考文献
Chemical Communications, , vol. 50, # 9 p. 1101 - 1103
反应条件
1: triethylamine / dichloromethane; hexane / 15 h / -40 - 20 °C / |Inert atmosphere 2: potassium carbonate; sodium iodide; (S)-(+)-2-((benzyloxy)diphenylmethyl)tetrahydrothiophene / acetonitrile / 48 h / |Inert atmosphere; |Schlenk technique 3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere 4: trifluoroacetic acid / water; acetone / 10 - 20 °C / |Inert atmosphere View Scheme
参考文献
Chemical Communications, , vol. 50, # 9 p. 1101 - 1103
参考文献
Saigo, Kazuhiko; Ogawa, Shigeo; Kikuchi, Shigetoshi; Kasahara, Atsushi; Nohira, Hiroyuki
Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 5 p. 1568 - 1573
反应条件
1: 78 percent / pyridine / 4 h / Ambient temperature 2: 2) NaBH4 / 1) Et2O, 12 h, room temperature, 2) THF, MeOH, -50 deg C, 4 h View Scheme
参考文献
Liebigs Annalen der Chemie, , # 3 p. 269 - 273
参考文献
Chemische Berichte, , vol. 65, p. 631,635
反应条件
sodium tetrahydroborate 1) Et2O, 12 h, room temperature, 2) THF, MeOH, -50 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Liebigs Annalen der Chemie, , # 3 p. 269 - 273
参考文献
Chemische Berichte, , vol. 65, p. 631,635
反应条件
1: With 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile T=20°C; 0.75 h; 2: With tributylphosphine; di-tert-butylazodicarboxylate in acetonitrile T=0°C; Mitsunobu reaction; 0.333333 h;
参考文献
Dinsmore, Christopher J.; Mercer, Swati P.
Organic Letters, 2004 , vol. 6, # 17 p. 2885 - 2888
反应条件
triethylamine in dichloromethane
参考文献
Akiba, Toshifumi; Tamura, Osamu; Hashimoto, Masaru; Kobayashi, Yuko; Katoh, Tadashi; et al.
Tetrahedron, 1994 , vol. 50, # 13 p. 3905 - 3914
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile T=20°C; 0.166667 h; 1.1 eq (Boc)2O;
参考文献
Knoelker, Hans-Joachim; Braxmeier, Tobias
Tetrahedron Letters, 1998 , vol. 39, # 51 p. 9407 - 9410
