萘并[2,1-d][1,3]噻唑合成路线 （共 5 条）
反应条件
1: aq. sodium sulfide / ethanol / 0.67 h / 85 °C 2: 5.4 g / H2SO4 / 0.33 h / 170 °C View Scheme
参考文献
Costanzo, Michael J.; Almond Jr., Harold R.; Hecker, Leonard R.; Schott, Mary R.; Yabut, Stephen C.; Zhang, Han-Cheng; Andrade-Gordon, Patricia; Corcoran, Thomas W.; Giardino, Edward C.; Kauffman, Jack A.; Lewis, Joan M.; De Garavilla, Lawrence; Haertlein, Barbara J.; Maryanoff, Bruce E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 1984 - 2008
反应条件
sulfuric acid T=170°C; 0.333333 h;
参考文献
Costanzo, Michael J.; Almond Jr., Harold R.; Hecker, Leonard R.; Schott, Mary R.; Yabut, Stephen C.; Zhang, Han-Cheng; Andrade-Gordon, Patricia; Corcoran, Thomas W.; Giardino, Edward C.; Kauffman, Jack A.; Lewis, Joan M.; De Garavilla, Lawrence; Haertlein, Barbara J.; Maryanoff, Bruce E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 1984 - 2008
反应条件
malonic acid in ethanol 288 h; Ambient temperature;
参考文献
Chaudhuri,A. et al.
Journal of the Indian Chemical Society, 1978 , vol. 55, p. 702 - 704
反应条件
malonic acid in ethanol 288 h; Ambient temperature;
参考文献
Chaudhuri,A. et al.
Journal of the Indian Chemical Society, 1978 , vol. 55, p. 702 - 704
反应条件
(i) S2Cl2, AcOH, benzene, (ii) NaHCO3, aq. NaOH, (iii) ZnCl2, aq. AcOH, NaOAc, (iv) /BRN= 1209246/, Zn; Multistep reaction;
参考文献
Wanzlick,H.-W. et al.
Justus Liebigs Annalen der Chemie, 1967 , vol. 708, p. 155 - 169
