4-[1,4]二氮杂烷-1-苯甲酸乙酯合成路线 （共 3 条）
反应条件
in dimethyl sulfoxide T=100°C; 24 h;
参考文献
ASTRAZENECA AB
Patent: US2008/153812 A1, 2008 ;
Location in patent: Page/Page column 140; 149-150 ;
US 20080153812 A1
反应条件
1: With hydrogenchloride in 1,4-dioxane; methanol T=20°C; 1 h; 2: With potassium carbonate in water
参考文献
Saito, Keiji; Nakao, Akira; Shinozuka, Tsuyoshi; Shimada, Kousei; Matsui, Satoshi; Oizumi, Kiyoshi; Yano, Kazuki; Ohata, Keiko; Nakai, Daisuke; Nagai, Yoko; Naito, Satoru
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 7 p. 1628 - 1642
反应条件
1: tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-dimethylamine / tert-butyl alcohol; 1,4-dioxane / 2 h / |Inert atmosphere; |Reflux 2: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C View Scheme
参考文献
Saito, Keiji; Nakao, Akira; Shinozuka, Tsuyoshi; Shimada, Kousei; Matsui, Satoshi; Oizumi, Kiyoshi; Yano, Kazuki; Ohata, Keiko; Nakai, Daisuke; Nagai, Yoko; Naito, Satoru
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 7 p. 1628 - 1642
