4-(4-(乙氧基羰基)苯基)哌嗪-1-羧酸叔丁酯合成路线 （共 7 条）
反应条件
potassium carbonate in dimethyl sulfoxide
参考文献
THERAVANCE, INC.
Patent: US2012/114600 A1, 2012 ;
反应条件
sodium hydroxide in water
参考文献
Meiji Seika Kaisha, Ltd.
Patent: US6451800 B1, 2002 ;
反应条件
sodium hydroxide in 1,4-dioxane; water T=20°C; 1 h;
参考文献
Kubota, Dai; Ishikawa, Minoru; Yamamoto, Mikio; Murakami, Shoichi; Hachisu, Mitsugu; Katano, Kiyoaki; Ajito, Keiichi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 7 p. 2089 - 2108
反应条件
1: 94 percent / dimethylsulfoxide / 20 h / 120 °C 2: NaOH / H2O; dioxane / 1 h / 20 °C View Scheme
参考文献
Kubota, Dai; Ishikawa, Minoru; Yamamoto, Mikio; Murakami, Shoichi; Hachisu, Mitsugu; Katano, Kiyoaki; Ajito, Keiichi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 7 p. 2089 - 2108
反应条件
1: With hydrogenchloride in 1,4-dioxane; dichloromethane 2: With potassium carbonate in water pH=10 - 11;
参考文献
ABBOTT LABORATORIES
Patent: US2010/184750 A1, 2010 ;
Location in patent: Page/Page column 46-47 ;
反应条件
1: sodium hydroxide / ethanol 2: hydrogenchloride; methanol View Scheme
参考文献
THERAVANCE, INC.
Patent: US2012/114600 A1, 2012 ;
反应条件
sodium hydroxide in ethanol
参考文献
THERAVANCE, INC.
Patent: US2012/114600 A1, 2012 ;
