(2-氯-3-碘-4-吡啶)氨基甲酸1,1-二甲基乙酯合成路线 （共 6 条）
反应条件
1: With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexanes T=-78°C; 4.25 h; 2: With iodine in tetrahydrofuran; hexanes T=-78°C; 2.25 h;
参考文献
OXAGEN LIMITED
Patent: WO2005/121141 A1, 2005 ;
Location in patent: Page/Page column 25-26 ;
WO 2005/121141 A1
反应条件
N-iodo-succinimide in tetrahydrofuran 1 h; Cooling with ether-dry ice;
参考文献
ALMIRALL, S.A.; VIDAL JUAN, Bernat; ALONSO DIEZ, Juan Antonio; BUIL ALBERO, Maria Antonia; EASTWOOD, Paul Robert; ESTEVE TRIAS, Cristina; LOZOYA TORIBIO, Maria Estrella; ROBERTS, Richard Spurring; VIDAL GISPERT, Laura; GONZALEZ RODRIGUEZ, Jacob; MIR CEPEDA, Marta
Patent: WO2013/10880 A1, 2013 ;
Location in patent: Page/Page column 94-95 ;
反应条件
in tetrahydrofuran 1 h; Cooling with ice;
参考文献
Almirall, S.A.; Vidal Juan, Bernat; Alonso Diez, Juan Antonio; Buil Albero, María Antonia; Eastwood, Paul Robert; Esteve Trias, Cristina; Lozoya Toribio, María Estrella; Roberts, Richard Spurring; Vidal Gispert, Laura
Patent: EP2548876 A1, 2013 ;
Location in patent: Paragraph 0370-0373 ;
EP 2548876 A1
反应条件
1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 - 55 °C 2: tetrahydrofuran / 1 h / Cooling with ice View Scheme
参考文献
Almirall, S.A.; Vidal Juan, Bernat; Alonso Diez, Juan Antonio; Buil Albero, María Antonia; Eastwood, Paul Robert; Esteve Trias, Cristina; Lozoya Toribio, María Estrella; Roberts, Richard Spurring; Vidal Gispert, Laura
Patent: EP2548876 A1, 2013 ;
EP 2548876 A1
反应条件
in methanol T=100°C; Inert atmosphere;
参考文献
WO2013/78254 A1, ;
Paragraph 00364 ;
反应条件
1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere; Cooling with acetone-dry ice
2: copper(l) iodide / N,N-dimethyl-formamide / 110 °C / Inert atmosphere
View Scheme
参考文献
ALMIRALL, S.A.; VIDAL JUAN, Bernat; ALONSO DIEZ, Juan Antonio; BUIL ALBERO, Maria Antonia; EASTWOOD, Paul Robert; ESTEVE TRIAS, Cristina; LOZOYA TORIBIO, Maria Estrella; ROBERTS, Richard Spurring; VIDAL GISPERT, Laura; GONZALEZ RODRIGUEZ, Jacob; MIR CEPEDA, Marta
Patent: WO2013/10880 A1, 2013 ;
