(1S,2R)-(-)-2-氨基-1,2-二苯基乙醇合成路线 （共 46 条）
反应条件
sodium amalgam; ethanol; acetic acid
参考文献
Soederbaum
Chemische Berichte, 1895 , vol. 28, p. 2522 Anm.
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Erlenmeyer; jun.
Chemische Berichte, 1896 , vol. 29, p. 297
Chemische Berichte, 1897 , vol. 30, p. 1525
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Goldschmidt; Polonowska
Chemische Berichte, 1887 , vol. 20, p. 494
反应条件
ethanol; nickel T=100 - 125°C; P=73550.8 - 110326 Torr; Hydrogenation;
参考文献
Winans; Adkins
Journal of the American Chemical Society, 1933 , vol. 55, p. 2051,2056
反应条件
1,4-dioxane; ammonia; water T=120°C;
参考文献
Jankowski,K.; Berse,C.
Canadian Journal of Chemistry, 1967 , vol. 45, p. 2865 - 2877
反应条件
ethanol; platinum T=70 - 75°C; Hydrogenation;
参考文献
Polonowska
Chemische Berichte, 1888 , vol. 21, p. 489
Full Text Show Details
Erlenmeyer; jun.
Chemische Berichte, 1896 , vol. 29, p. 297
Chemische Berichte, 1897 , vol. 30, p. 1525
反应条件
sodium bis(2-methoxyethoxy)aluminium dihydride in toluene; benzene 3 h; Heating;
参考文献
Miyata, Okiko; Koizumi, Tomoko; Asai, Hiroshi; Iba, Ryuichi; Naito, Takeaki
Tetrahedron, 2004 , vol. 60, # 17 p. 3893 - 3914
反应条件
ethanol; nickel T=70 - 90°C; Hydrogenation;
参考文献
Winans; Adkins
Journal of the American Chemical Society, 1933 , vol. 55, p. 4167,4169, 4173
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 6 h; Heating;
参考文献
Miyata, Okiko; Koizumi, Tomoko; Asai, Hiroshi; Iba, Ryuichi; Naito, Takeaki
Tetrahedron, 2004 , vol. 60, # 17 p. 3893 - 3914
反应条件
1: phosphorus pentachloride / benzene / 2 h / 0 °C 2: 65 mg / sodium hydride / tetrahydrofuran / 2 h / Heating 3: 89 percent / lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / -23 °C 4: 100 percent / 2,6-lutidine / CH2Cl2 / 1 h / 20 °C 5: LiAlH4 / tetrahydrofuran / 7 h / 0 °C 6: 40 mg / p-toluenesulfonic acid / methanol / 3 h / 20 °C View Scheme
参考文献
Miyata, Okiko; Koizumi, Tomoko; Asai, Hiroshi; Iba, Ryuichi; Naito, Takeaki
Tetrahedron, 2004 , vol. 60, # 17 p. 3893 - 3914
反应条件
1: 65 mg / sodium hydride / tetrahydrofuran / 2 h / Heating 2: 89 percent / lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / -23 °C 3: 100 percent / 2,6-lutidine / CH2Cl2 / 1 h / 20 °C 4: LiAlH4 / tetrahydrofuran / 7 h / 0 °C 5: 40 mg / p-toluenesulfonic acid / methanol / 3 h / 20 °C View Scheme
参考文献
Miyata, Okiko; Koizumi, Tomoko; Asai, Hiroshi; Iba, Ryuichi; Naito, Takeaki
Tetrahedron, 2004 , vol. 60, # 17 p. 3893 - 3914
反应条件
1: 99 percent / pyridine / CH2Cl2 / 2 h / 20 °C 2: phosphorus pentachloride / benzene / 2 h / 0 °C 3: 65 mg / sodium hydride / tetrahydrofuran / 2 h / Heating 4: 89 percent / lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / -23 °C 5: 100 percent / 2,6-lutidine / CH2Cl2 / 1 h / 20 °C 6: LiAlH4 / tetrahydrofuran / 7 h / 0 °C 7: 40 mg / p-toluenesulfonic acid / methanol / 3 h / 20 °C View Scheme
参考文献
Miyata, Okiko; Koizumi, Tomoko; Asai, Hiroshi; Iba, Ryuichi; Naito, Takeaki
Tetrahedron, 2004 , vol. 60, # 17 p. 3893 - 3914
