6-甲氧基-[1,5]-萘啶-4-醇合成路线 （共 11 条）
反应条件
in diphenylether T=260°C;
参考文献
Gomez, Laurent; Hack, Michael D.; Wu, Jiejun; Wiener, John J.M.; Venkatesan, Hari; Santillan Jr., Alejandro; Pippel, Daniel J.; Mani, Neelakandha; Morrow, Brian J.; Motley, S. Timothy; Shaw, Karen Joy; Wolin, Ronald; Grice, Cheryl A.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 10 p. 2723 - 2727
反应条件
dowtherm A 0.383333 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM P.L.C.
Patent: WO2003/87098 A1, 2003 ;
Location in patent: Page/Page column 37 ;
参考文献
Davies, David Thomas; Markwell, Roger Edward; Pearson, Neil David
Patent: US2004/53928 A1, 2004 ;
反应条件
in diphenylether T=250°C;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; VU, Chi, B.; CASAUBON, Rebecca, L.
Patent: WO2010/101949 A1, 2010 ;
Location in patent: Page/Page column 125 ;
WO 2010/101949 A1
反应条件
in dowtherm A 0.383333 h; Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/20561 A2, 2006 ;
Location in patent: Page/Page column 29 ;
反应条件
1: 6-Methoxy-pyridin-3-ylamine; 2,2-Dimethyl-[1,3]dioxane-4,6-dione With orthoformic acid triethyl ester in ethanol 3 h; Heating / reflux; 2: diphenylether T=260°C; 0.05 h; Heating / reflux;
参考文献
MORPHOCHEM AKTIENGESELLSCHAFT FUeR KOMBINATORISCHE CHEMIE
Patent: WO2006/21448 A1, 2006 ;
Location in patent: Page/Page column 28 ;
反应条件
in quinoline 2 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM PLC
Patent: EP1214314 B1, 2005 ;
Location in patent: Page/Page column 15 ;
反应条件
1: ethanol / 3 h / 80 °C / |Inert atmosphere 2: diphenylether / 0.17 h / 220 °C View Scheme
参考文献
KYORIN PHARMACEUTICAL CO., LTD.; MERCK SHARP and DOHME CORP.; FUKUDA, Yasumichi; KAELIN, David E. Jr.; SINGH, Sheo B.
Patent: WO2013/3383 A1, 2013 ;
反应条件
1.1: sulfuric acid; silica gel / 0.08 h 1.2: 27 h / 80 °C / |Inert atmosphere 2.1: phosphorus tribromide / N,N-dimethyl-formamide / 1 h / 50 - 70 °C View Scheme
参考文献
ACTELION PHARMACEUTICALS LTD; ABELE, Stefan; MEIER, Hans; SCHMIDT, Gunther; STEINER, Heinz
Patent: WO2013/160875 A1, 2013 ;
反应条件
1: With trichlorophosphate T=110°C; 12 h; 2: With water; sodium hydrogencarbonate T=0°C; pH=7;
参考文献
SMITHKLINE BEECHAM PLC
Patent: EP1214314 B1, 2005 ;
Location in patent: Page/Page column 15 ;
