反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride in tetrahydrofuran
T=-40 - 20°C; 1 h; Inert atmosphere;
2: n-tridecyl methyl ketone in tetrahydrofuran
T=-40 - 20°C; Horner-Wadsworth-Emmons olefination; 18 h; Inert atmosphere;
3: With ammonium chloride in tetrahydrofuran; diethyl ether; water
参考文献
Milite, Ciro; Castellano, Sabrina; Benedetti, Rosaria; Tosco, Alessandra; Ciliberti, Carmen; Vicidomini, Caterina; Boully, Ludovic; Franci, Gianluigi; Altucci, Lucia; Mai, Antonello; Sbardella, Gianluca
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 12 p. 3690 - 3701
