2-氨基-5-硝基苯硫醇合成路线 （共 18 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=50°C; 16 h;
参考文献
Thomas, Richard Charles; Poel, Toni-Jo; Barbachyn, Michael Robert; Gordeev, Mikhail Fedor; Luehr, Gary W.; Renslo, Adam; Singh, Upinder; Josyula, Vara Prasad Venkata Nagendra
Patent: US2004/147760 A1, 2004 ;
Location in patent: Page 70 ;
反应条件
1: 2-amino-5-nitrobenzothiole With sodium hydrogencarbonate in tetrahydrofuran; water 2: chloroacetyl chloride in tetrahydrofuran; water T=20°C;
参考文献
Ramnauth, Jailall; Annedi, Subhash C.; Silverman, Sarah; Dove, Peter; Maddaford, Shawn; Rakhit, Suman
Patent: US2010/9975 A1, 2010 ;
Location in patent: Page/Page column 40 ;
US 20100009975 A1
反应条件
sulfuric acid; sodium nitrite
参考文献
RADIUS HEALTH, INC.; MILLER, Chris, P.
Patent: WO2012/47617 A1, 2012 ;
Location in patent: Page/Page column 44 ;
WO 2012/047617 A1
反应条件
1: benzene 2: tin; aqueous HCl View Scheme
参考文献
Babitschew et al.
Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1956 , vol. 22, p. 514,516
Chem.Abstr., 1957 , p. 5051
参考文献
Mylius
Dissertation <Berlin 1883>, S. 48
Full Text Show Details
Jacobson; Kwaysser
Justus Liebigs Annalen der Chemie, 1893 , vol. 277, p. 244
参考文献
Mylius
Dissertation <Berlin 1883>, S. 48
反应条件
1: With hydrazine hydrate in ethanol
T=20°C;
2: With hydrogenchloride in ethanol; water
Product distribution / selectivity;
参考文献
Ramnauth, Jailall; Annedi, Subhash C.; Silverman, Sarah; Dove, Peter; Maddaford, Shawn; Rakhit, Suman
Patent: US2010/9975 A1, 2010 ;
Location in patent: Page/Page column 43-44 ;
US 20100009975 A1
反应条件
potassium hydroxide in water; ethylene glycol
T=140°C; 24 h;
参考文献
Hirose, Wataru; Sato, Kousuke; Matsuda, Akira
European Journal of Organic Chemistry, 2011 , # 31 p. 6206 - 6217
反应条件
1.1: bromine; acetic acid / 0.5 h / 10 °C
1.2: 19 h / 10 °C
2.1: potassium hydroxide / water; ethylene glycol / 24 h / 140 °C
View Scheme
参考文献
Hirose, Wataru; Sato, Kousuke; Matsuda, Akira
European Journal of Organic Chemistry, 2011 , # 31 p. 6206 - 6217
参考文献
Colonna; Andrisano
Bollettino Scientifico della Facolta di Chimica Industriale di Bologna, 1943 , vol. 4, p. 70
