1: 4-Dimethylamino-2-methylbenzaldehyde With sodium thiosulfate in ethanol; water Heating / reflux; 2: 2-amino-4-lt;5'-(4''-methylpiperazin-1''-yl)benzimidazol-2'-ylgt;aniline in ethanol; water 24 h; Heating / reflux;
参考文献
Peter MacCallum Cancer Institute
Patent: EP2044938 A2, 2009 ;
Location in patent: Page/Page column 21 ;