1-(2,3-二氯-4-羟基苯基)-1-丁酮合成路线 （共 4 条）
反应条件
hydrogenchloride; sodium hydroxide; aluminium trichloride in carbon disulfide; n-heptane; water
参考文献
Dude, Marie-Adrienne; Kaeppler, Ulrich; Herb, Monika; Schiller, Markus; Schulz, Franziska; Vedder, Birgit; Heppner, Saskia; Pradel, Gabriele; Gut, Jiri; Rosenthal, Philip J.; Schirmeister, Tanja; Leippe, Matthias; Gelhaus, Christoph
Molecules, 2009 , vol. 14, # 1 p. 19 - 35
反应条件
AlCl3, aluminium chloride in carbon disulfide Friedel-Crafts Acylation;
参考文献
Janser, Ingo; Vortolomei, Caitlyn M.; Meka, Ranjith K.; Walsh, Courtney A.; Janser, Romy F.J.
Comptes Rendus Chimie, 2013 , vol. 16, # 7 p. 660 - 664
反应条件
1: potassium carbonate / acetone / 48 h / |Reflux 2: potassium carbonate / ethanol; water / 24 h / |Reflux View Scheme
参考文献
Janser, Ingo; Vortolomei, Caitlyn M.; Meka, Ranjith K.; Walsh, Courtney A.; Janser, Romy F.J.
Comptes Rendus Chimie, 2013 , vol. 16, # 7 p. 660 - 664
反应条件
1: 1.) K2CO3, 2.) NaOH / 1.) DMF, 55-60 deg C, 16.5 h, 2.) H2O, 100 deg C, 2 h 2: 1.) Me2NH*HCl / 1.) AcOH, steam bath, 7 h, 2.) DMF, 60 deg C, 1 h View Scheme
参考文献
Abraham, D. J.; Mehanna, A. S.; Williams, F. S.; Cragoe, E. J.; Woltersdorf, O. W.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2460 - 2467
